TY - JOUR T1 -儿童哮喘的诊断:来自瑞士儿科气道队列JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.00132-2020 SP - 2000132 AU - de Jong, Carmen CM。Eva SL。非盟盟- Pedersen——Mozun Rebeca盟——Muller-Suter杜米尼克AU - Jochmann,安雅盟——歌手,Florian盟——Casaulta卡门盟——Regamey尼古拉斯AU -穆勒,亚历山大盟——Ardura-Garcia克里斯蒂娜盟——Kuehni克劳迪娅E Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/05/29/13993003.00132 - 2020. -抽象N2 -介绍诊断哮喘儿童仍然是一个挑战,因为呼吸道症状不是特定的,随着时间推移而改变。在一项现实生活中的观察性研究中，我们评估了呼吸道症状、客观测试和GINA和NICE提出的用于诊断学龄儿童哮喘的两种儿科诊断算法的诊断准确性。方法对5-17岁连续转诊至肺部门诊进行疑似哮喘评估的儿童进行研究。通过家长问卷对症状进行评估。研究包括特异性IgE测量或皮肤点刺试验、呼出一氧化氮分数测量、肺活量测量、体容积描记术和支气管扩张剂可逆性。哮喘由儿科肺科医生根据所有可用数据诊断。我们通过计算敏感性、特异性、阳性和阴性预测值以及曲线下面积(AUC)来评估症状、测试和诊断算法的诊断准确性。在514名参与者中，357人(70%)被诊断为哮喘。灵敏度和特异性(灵敏度/特异性)在任何喘息(0.75/0.65)、呼吸困难(0.56/0.76)和由感冒(0.58/0.78)或运动(0.55/0.74)引发的喘息(0.55/0.74)中都是最高的。在诊断试验中，比总阻力(sRtot)最高(0.73)，剩余容积(RV)总肺活量(TLC)比最低(0.56)。NICE算法灵敏度为0.69，特异性为0.67，而GINA算法灵敏度为0.42，特异性为0.90。结论本研究证实了单一检测方法和现有算法在哮喘诊断中的局限性。它强调需要新的和更适当的循证指导。FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. de Jong has nothing to disclose.Conflict of interest: Dr. Pedersen has nothing to disclose.Conflict of interest: Dr. Mozun has nothing to disclose.Conflict of interest: Dr. Mueller-Suter has nothing to disclose.Conflict of interest: Dr. Jochmann has nothing to disclose.Conflict of interest: Dr. Singer reports grants from CFCH, personal fees from Novartis, personal fees from Vertex, outside the submitted work;.Conflict of interest: Dr. Casaulta has nothing to disclose.Conflict of interest: Dr. Regamey has nothing to disclose.Conflict of interest: Dr. Moeller has nothing to disclose.Conflict of interest: Dr. Ardura-Garcia has nothing to disclose.Conflict of interest: Dr. Kuehni has nothing to disclose. ER -