RT期刊论文SR电子T1儿童哮喘的诊断：来自瑞士的儿科呼吸道队列JF欧洲呼吸杂志JO欧元呼吸杂志FD欧洲呼吸学会SP 2000132发现DO 10.1183 / 13993003.00132-2020 A1德容，卡门CM。188bet官网地址A1佩德森，伊娃SL。A1魔尊，丽贝卡A1穆勒 - 苏特，多米尼克A1 Jochmann，安雅A1歌手，弗洛里安A1 Casaulta，卡门A1 Regamey，萨科A1默勒，亚历山大A1 Ardura加西亚，克里斯蒂娜A1 Kuehni，克劳迪娅ēYR 2020 UL的http：// ERJ。儿童ersjournals.com/content/early/2020/05/29/13993003.00132-2020.abstract AB简介诊断哮喘仍然是一个挑战，因为呼吸道症状不特异，并改变了time.Aim在现实生活中的观察研究，我们评估the diagnostic accuracy of respiratory symptoms, objective tests, and two paediatric diagnostic algorithms proposed by GINA and NICE to diagnose asthma in school-aged children.Methods We studied children aged 5–17 years referred consecutively for evaluation of suspected asthma to pulmonary outpatient clinics. Symptoms were assessed by parental questionnaire. The investigations included specific IgE measurement or skin prick tests, measurement of fractional exhaled nitric oxide, spirometry, body plethysmography, and bronchodilator reversibility. Asthma was diagnosed by paediatric pulmonologists based on all available data. We assessed diagnostic accuracy of symptoms, tests, and diagnostic algorithms by calculating sensitivity, specificity, positive and negative predictive values, and area under the curve (AUC).Results Among 514 participants, 357(70%) were diagnosed with asthma. The combined sensitivity and specificity (sensitivity/specificity) was highest for any wheeze (0.75/0.65), dyspnoea (0.56/0.76), and wheeze triggered by colds (0.58/0.78) or by exercise (0.55/0.74). Of the diagnostic tests, the AUC was highest for specific total resistance (sRtot) (0.73) and lowest for the residual volume (RV) total lung capacity (TLC) ratio (0.56). The NICE algorithm had a sensitivity of 0.69 and specificity of 0.67, whereas the GINA algorithm had a sensitivity of 0.42 and specificity of 0.90.Conclusion This study confirms the limited usefulness of single tests as well as existing algorithms for the diagnosis of asthma. It highlights the need for new and more appropriate evidence-based guidance.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. de Jong has nothing to disclose.Conflict of interest: Dr. Pedersen has nothing to disclose.Conflict of interest: Dr. Mozun has nothing to disclose.Conflict of interest: Dr. Mueller-Suter has nothing to disclose.Conflict of interest: Dr. Jochmann has nothing to disclose.Conflict of interest: Dr. Singer reports grants from CFCH, personal fees from Novartis, personal fees from Vertex, outside the submitted work;.Conflict of interest: Dr. Casaulta has nothing to disclose.Conflict of interest: Dr. Regamey has nothing to disclose.Conflict of interest: Dr. Moeller has nothing to disclose.Conflict of interest: Dr. Ardura-Garcia has nothing to disclose.Conflict of interest: Dr. Kuehni has nothing to disclose.