Ty-jour t1 - 肺组织中的共甲基化分析识别COPD JF - 欧洲呼吸期刊Jo - EUR RESPIR J Do - 10.1183 / 13993003 - 1902347 Au - Kachroo，Priyadarshini Au - 明天，Jarrett D。Au - Kho，Alvin T. Au - Vyhlidal，Carrie A. Au - Silverman，Edwin K. Au - Weiss，Scott T. Au - Tantisira，Kelan G. Au - Demeo，Dawn L. Y1 - 2020/01/01UR - //www.qdcxjkg.com/content/early/2020/05/26/1399300/26/13993003.02347-2019.Abstract n2 - 慢性阻塞性肺病（COPD）可能具有发育起源，但潜在的分子机制没有完全识别。使用网络方法的DNA甲基化等肺组织特异性表观遗传修饰的调查可能促进与Utto烟雾（IUS）暴露的洞察力和Adulthood中COPD的风险。我们对160个外科样品进行了成人肺DNA的基因组甲基化分析78胎儿肺DNA样品从妊娠8至18周的丢弃组织中分离。构建共甲基化网络以鉴定保存的模块，即胎儿和成人肺组织中的甲基化模式和胎儿IUS暴露，妊娠期和COPD的关联。重量相关网络突出显示了胎儿和成人肺数据的保存和共甲基化模块胎儿IUS-曝光，COPD和较低的成人肺功能。这些模块被显着富集参与胚胎器官发育和特异性炎症相关途径，包括河马，PI3K / AKT，WNT，MAP-激酶和TGF-β信号传导。对于COPD和肺功能显着保留了妊娠期相关的模块，并且还被注释为富含WNT和PI3K / AKT途径的基因。诱发网络肺组织的预兆网络扰动，暴露于IUS和早期肺部肺部的成人肺组织综合前吸烟者有COPD。重叠的胎儿和成人肺组织网络模块强调推定的疾病途径，支持与欧洲呼吸杂志的出版物最近被接受过曝光相关和年龄相关的发育起源。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Kachroo has nothing to disclose.Conflict of interest: Dr. Morrow reports grants from National Institutes of Health, during the conduct of the study.Conflict of interest: Dr. Kho has nothing to disclose.Conflict of interest: Dr. Vyhlidal reports grants from NIH, during the conduct of the study.Conflict of interest: Dr. Silverman reports grants from NIH, during the conduct of the study; grants and other support from GlaxoSmithKline and grants from Bayer, outside the submitted work.Conflict of interest: Dr. Weiss reports personal fees from UpToDate, outside the submitted work.Conflict of interest: Dr. Tantisira reports grants from National Institutes of Health, during the conduct of the study.Conflict of interest: Dr. DeMeo reports grants from National Institutes of Health, during the conduct of the study and grants from Bayer, outside the submitted work. ER -