@article {Halpin1901921作者={哈尔平,大卫M.G. Dransfield,马克·t·汉,梅兰k和琼斯,c·伊莱恩和基尔布赖德,莎莉和兰格,彼得和利普森,大卫·a·洛玛斯,大卫·a·马丁内斯,费尔南多·J·帕斯科,史蒂夫和辛格,戴夫和明智,罗伯特。克里内,杰拉德J。},标题={恶化的影响历史的结果影响审判},体积= {55}= {5},elocation-id = {1901921} = {2020}, doi ={10.1183/13993003.01921 -2019},出版商={欧洲呼吸学会},文摘={影响,52周,随机,双盲试验,评估的有效性和安全性fluticasone糠酸盐/ umeclidinium vilanterol (FF / UMEC /188bet官网地址 VI)三联疗法和FF / VI或UMEC / VI在慢性阻塞性肺病患者症状和发作的历史。子群分析评估的有效性是否FF / UMEC / VI和FF / VI或UMEC / VI和UMEC / VI和FF / VI变化根据之前恶化的历史,和恶化的历史和血液嗜酸性粒细胞计数。三个子组被定义:单温和(1中度/不严重;n = 3056(30 \ %)),频繁温和(> = 2中度/不严重;n = 4628(45 \ %))和严重(> = 1严重/任何温和;n = 2671 (26 \ %))。终端包括年度治疗中度/重度恶化率(预先确定),肺功能和健康状况(因果)。中度/重度恶化率(降低\ % (95 \ % CI))减少FF / UMEC /第六组和FF / VI(单一温和20 \ % (10 {\ textendash} 29),频繁的温和11 \ % (2 {\ textendash} 19),严重17 \ % 26 (7 {\ textendash}))和与UMEC / VI(单一温和18 \ % (5 {\ textendash} 29),频繁的温和29 \ % (21 {\ textendash} 37),严重26 \ % (14 35 {\ textendash}))。中度/重度恶化率减少了FF /第六组与UMEC / VI频繁的温和的子群;观察数值减少严重的子群(单一温和2 \ % (-12 {\ textendash} 18),频繁的温和21 \ % (11 {\ textendash} 29),严重11 \ % 22 (3 {\ textendash}))。 Moderate/severe exacerbation rates were lower in the FF/VI group compared with UMEC/VI in patients with higher eosinophil counts. FF/UMEC/VI improved lung function and health status versus both dual therapies irrespective of exacerbation subgroup. UMEC/VI improved lung function versus FF/VI in all subgroups.Triple therapy was more effective than dual regardless of exacerbation history, consistent with results in the intent-to-treat population. Comparisons between dual therapies were influenced by prior exacerbation history and eosinophil counts.FF/UMEC/VI shows benefits vs FF/VI and UMEC/VI across multiple endpoints irrespective of exacerbation history. Exacerbation history and eosinophils influenced the comparison between UMEC/VI and FF/VI, and eosinophils that between FF/UMEC/VI and UMEC/VI. http://bit.ly/2SHu2ey}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/5/1901921}, eprint = {//www.qdcxjkg.com/content/55/5/1901921.full.pdf}, journal = {European Respiratory Journal} }