长期功能结局RT期刊论文SR电子T1结构性因素在年幼的孩子患有囊性纤维化JF欧洲呼吸杂志JO欧元呼吸杂志FD欧洲呼吸学会SP 1900748 DO 10.1183 / 13993003.00748-2019 VO 55 5 A1 Turkovic，利迪A1 Caudri188bet官网地址, Daan A1 Rosenow, Tim A1 Breuer, Oded A1 Murray, Conor A1 Tiddens, Harm A.W.M. A1 Ramanauskas, Fiona A1 Ranganathan, Sarath C. A1 Hall, Graham L. A1 Stick, Stephen M. YR 2020 UL //www.qdcxjkg.com/content/55/5/1900748.abstract AB Background Accelerated lung function decline in individuals with cystic fibrosis (CF) starts in adolescence with respiratory complications being the most common cause of death in later life. Factors contributing to lung function decline are not well understood, in particular its relationship with structural lung disease in early childhood. Detection and management of structural lung disease could be an important step in improving outcomes in CF patients.Methods Annual chest computed tomography (CT) scans were available from 2005 to 2016 as a part of the AREST CF cohort for children aged 3 months to 6 years. Annual spirometry measurements were available for 89.77% of the cohort (167 children aged 5–6 years) from age 5 to 15 years through outpatient clinics at Perth Children's Hospital (Perth, Australia) and The Royal Children's Hospital in Melbourne (Melbourne, Australia) (697 measurements, mean±sd age 9.3±2.1 years).Results Children with a total CT score above the median at age 5–6 years were more likely to have abnormal forced expiratory volume in 1 s (FEV1) (adjusted hazard ratio 2.67 (1.06–6.72), p=0.037) during the next 10 years compared to those below the median chest CT score. The extent of all structural abnormalities except bronchial wall thickening were associated with lower FEV1 Z-scores. Mucus plugging and trapped air were the most predictive sub-score (adjusted mean change −0.17 (−0.26 – −0.07) p<0.001 and −0.09 (−0.14 – −0.04) p<0.001, respectively).Discussion Chest CT identifies children at an early age who have adverse long-term outcomes. The prevention of structural lung damage should be a goal of early intervention and can be usefully assessed with chest CT. In an era of therapeutics that might alter disease trajectories, chest CT could provide an early readout of likely long-term success.Structural lung changes identified on a chest CT scan in children with cystic fibrosis under 6 years of age can identify those at risk of adverse long-term outcomes http://bit.ly/39QH5jv