PT - 日刊文AU - 关，卫杰盟 - 梁启超文华盟 - 赵易非盟 - 梁启超恒锐AU - 陈梓生AU - 李，易敏AU - 刘，Xiao-清AU - 陈儒崇AU - 唐春利AU - 王滔AU - 欧，春全盟 - 李，李盟 - 陈，平欣AU - 桑，凌AU - 王，魏AU- 李，建福AU - 李，蔡辰AU - 欧，李民AU - 诚，博AU - 熊，山盟 - 倪，郑毅AU - 翔杰AU - 胡，俞AU - 刘，雷盟 - 山，香港AU - 雷春亮AU - 鹏，宜香AU - 伟，李AU - 刘雍AU - 胡，雅华盟 - 彭，彭AU - 王，建明AU - 刘霁阳AU - 陈，钟AU - 李，刚AU - 郑，志坚AU - 秋，邵琴AU - 罗，捷盟 - 烨，常江AU - 朱邵勇AU - 郑，林龄AU - 野，冯AU - 李，施跃AU - 郑，金平AU - 张，诺富AU - 钟，南山AU - 他，建星ED - ，TI - 合并症和其在中国的对1590例患者的影响有COVID-19：全国范围分析AID - 10.1183 / 13993003.00547-2020 DP - 2020年05月01日TA- 欧洲呼吸杂志PG - 2000547 VI - 55 IP - 5 4099 - 4100 //www.qdcxjkg.com/content/55/5/2000547.short - //www.qdcxjkg.com/content/55/5 / 2000547.full SO - 欧洲呼吸J2020 05月01日;55 AB - 背景冠状病毒病2019（COVID-19）疫情发展迅速worldwide.Objective要通过分层的合并症status.Methods我们分析的数据来自1590例实验室确认的住院病人评价严重不良后果的风险，患者COVID-19从2019年12月11日和31日之间575家医院在31个省/自治区/省在中国大陆直辖市一月2020我们分析了复合终点，其中包括入院到重症监护病房，有创通气或死亡。The risk of reaching the composite end-points was compared according to the presence and number of comorbidities.Results The mean age was 48.9 years and 686 (42.7%) patients were female. Severe cases accounted for 16.0% of the study population. 131 (8.2%) patients reached the composite end-points. 399 (25.1%) reported having at least one comorbidity. The most prevalent comorbidity was hypertension (16.9%), followed by diabetes (8.2%). 130 (8.2%) patients reported having two or more comorbidities. After adjusting for age and smoking status, COPD (HR (95% CI) 2.681 (1.424–5.048)), diabetes (1.59 (1.03–2.45)), hypertension (1.58 (1.07–2.32)) and malignancy (3.50 (1.60–7.64)) were risk factors of reaching the composite end-points. The hazard ratio (95% CI) was 1.79 (1.16–2.77) among patients with at least one comorbidity and 2.59 (1.61–4.17) among patients with two or more comorbidities.Conclusion Among laboratory confirmed cases of COVID-19, patients with any comorbidity yielded poorer clinical outcomes than those without. A greater number of comorbidities also correlated with poorer clinical outcomes.The presence and number of comorbidities predict clinical outcomes of COVID-19 http://bit.ly/3b9ibw5