Ty-jour t1 - 嗜酸性粒细胞，嗜碱性粒细胞和2型免疫微环境在Copd受影响的肺组织JF - 欧洲呼吸杂志Jo - Eur Respir J Do - 10.1183 / 13993003.00110-2019 VL - 55是 - 5 SP - 1900110 Au - Jogdand，PrajaktaAu - Siddhuraj，Premkumar Au - Mori，Michiko Au - Sanden，Caroline Au - Jönsson，Jimmie Au - Walls，Andrew F. Au - Kearley，Jennifer Au - Humbles，Alison A. Au - Kolbeck，Roland Au - Bjermer，Leif Au- 纽比尔德，保罗奥卢 - 埃尔约维斯，乔纳斯S. y1 - 2020 / 05/01 UR - //www.qdcxjkg.com/content/55/5/1900110.Abstract n2 - 虽然存在升高的血液或痰液嗜纤度粒细胞许多患者患有COPD，不确定性仍然是肺渗透嗜酸性粒细胞的解剖分布模式。缓慢性在COPD中几乎没有探索。该研究映射了组织渗透嗜酸性粒细胞，嗜碱性粒细胞和嗜酸性粒细胞促进了COPD受影响的肺部的免疫机制。从COPD患者中获得了来自主要解剖室的肺组织和活检，从COPD患者获得了慢性阻塞性肺病阶段I-IV的全局倡议;从不吸烟/吸烟者作为控制。自动免疫组织化学和原位杂交鉴定的免疫细胞，2型免疫标记GATA3和Eotaxins（CCL11，CCL24）。在COPD受影响的肺部的所有解剖室中存在，并且在非常严重的COPD中显着增加。嗜酸性粒细胞凋亡均匀，富含嗜酸性嗜酸性粒细胞的微环境在空间上与GATA3 +细胞连接，包括2型辅助T细胞淋巴细胞和2型先天淋巴细胞。在流感感染的小鼠中证明了类似局部化的和白细胞介素-33 / ST2依赖性嗜酸性粒细胞症。 Both mice and patients displayed spatially confined eotaxin signatures with CCL11+ fibroblasts and CCL24+ macrophages.In addition to identifying tissue basophilia as a novel feature of advanced COPD, the identification of spatially confined eosinophil-rich type 2 microenvironments represents a novel type of heterogeneity in the immunopathology of COPD that is likely to have implications for personalised treatment.Highly localised Th2- and eosinophil-rich pockets were identified in COPD-affected lungs, which increased in number with increasing disease severity and included basophils. This exemplifies a novel type of heterogeneity in the immunopathology of COPD. http://bit.ly/2HexTco ER -