PT -期刊文章盟Prajakta Jogdand AU - Premkumar Siddhuraj AU -美智子Mori盟卡罗琳Sanden盟——吉米·琼森盟——安德鲁·f·墙壁AU -珍妮弗Kearley盟艾莉森·a .教训了非盟-罗兰Kolbeck盟列夫Bjermer AU -保罗·纽伯尔德盟乔纳斯美国Erjefalt TI -嗜酸性粒细胞,嗜碱性粒细胞和2型免疫微环境COPD-affected肺组织援助- 10.1183/13993003.00110 -2019 DP - 2020年5月01 TA -欧洲呼吸杂志》第六PG - 1900110 - 55 IP - 5 4099 - //www.qdcxjkg.com/content/55/5/1900110.short 4100 - //www.qdcxjkg.com/content/55/5/1900110.full所以欧元和J2020可能01;55 AB——尽管升高血或痰嗜酸性粒细胞存在在许多慢性阻塞性肺病患者,不确定性仍然lung-infiltrating嗜酸性粒细胞的解剖分布格局。嗜碱粒细胞一直在慢性阻塞性肺病几乎未被探索。本研究映射tissue-infiltrating嗜酸性粒细胞、嗜碱性粒细胞和eosinophil-promoting COPD-affected肺的免疫机制。外科肺组织活检和主要解剖室获得慢性阻塞性肺病患者的严重程度等级为慢性阻塞性肺疾病阶段I-IV全球倡议;不吸烟者和吸烟者作为控制。免疫细胞自动免疫组织化学和原位杂交鉴定,2型免疫标记GATA3和eotaxins (CCL11 CCL24)。嗜酸性细胞和嗜碱性细胞,在所有COPD-affected肺的解剖室和非常严重的慢性阻塞性肺病的显著增加。嗜酸性粒细胞明显不足,焦eosinophil-rich微环境是空间与GATA3 +细胞,包括2型辅助t细胞淋巴细胞和2型先天淋巴细胞。同样在为本地化和interleukin-33 / ST2-dependent嗜酸细胞增多症influenza-infected老鼠。老鼠和患者显示空间限制eotaxin签名CCL11 +纤维母细胞和CCL24 +巨噬细胞。In addition to identifying tissue basophilia as a novel feature of advanced COPD, the identification of spatially confined eosinophil-rich type 2 microenvironments represents a novel type of heterogeneity in the immunopathology of COPD that is likely to have implications for personalised treatment.Highly localised Th2- and eosinophil-rich pockets were identified in COPD-affected lungs, which increased in number with increasing disease severity and included basophils. This exemplifies a novel type of heterogeneity in the immunopathology of COPD. http://bit.ly/2HexTco