%0期刊文章%A Jogdand, Prajakta %A Siddhuraj, Premkumar %A Mori, Michiko %A Sanden, Caroline %A Jönsson, Jimmie %A Walls, Andrew F. %A Kearley, Jennifer %A Humbles, Alison A. %A Kolbeck, Roland %A Bjermer, Leif %A Newbold, Paul %A Erjefält, Jonas S. %T嗜酸性粒细胞，慢性阻塞性肺病(COPD)患者肺组织中嗜碱性粒细胞和2型免疫微环境的变化肺浸润性嗜酸性粒细胞的解剖分布模式仍不确定。嗜碱性粒细胞在慢性阻塞性肺病中的作用尚未被发现。这项研究在慢性阻塞性肺病感染的肺中绘制了组织浸润的嗜酸性粒细胞、嗜碱性粒细胞和促进嗜酸性粒细胞的免疫机制。来自主要解剖室的外科肺组织和活组织切片取自全球慢性阻塞性肺病行动计划(Global Initiative for Chronic Obstructive lung Disease, Global Initiative) I-IV级严重程度的COPD患者;不吸烟/不吸烟的人作为对照。自动免疫组化和原位杂交鉴定了免疫细胞、2型免疫标记物GATA3和eotaxins (CCL11, CCL24)。嗜酸性粒细胞和嗜碱性粒细胞在COPD影响的肺的所有解剖室中都存在，在非常严重的COPD中显著增加。嗜酸性粒细胞明显呈斑片状，局灶性富含嗜酸性粒细胞的微环境与GATA3+细胞(包括2型辅助性t细胞和2型固有淋巴细胞)在空间上存在联系。在流感感染小鼠中发现了一种类似的局部和白细胞介素-33/ st2依赖的嗜酸性粒细胞病。 Both mice and patients displayed spatially confined eotaxin signatures with CCL11+ fibroblasts and CCL24+ macrophages.In addition to identifying tissue basophilia as a novel feature of advanced COPD, the identification of spatially confined eosinophil-rich type 2 microenvironments represents a novel type of heterogeneity in the immunopathology of COPD that is likely to have implications for personalised treatment.Highly localised Th2- and eosinophil-rich pockets were identified in COPD-affected lungs, which increased in number with increasing disease severity and included basophils. This exemplifies a novel type of heterogeneity in the immunopathology of COPD. http://bit.ly/2HexTco %U //www.qdcxjkg.com/content/erj/55/5/1900110.full.pdf