%0期刊文章%A Gallacher, David %A Mitchell, Emma %A Alber, Dagmar %A Wach, Richard %A Klein, Nigel %A Marchesi, Julian R. %A Kotecha，Sailesh % T gut-lung轴的不同和失调降低航空公司的通风早产儿% D J 2020% R 10.1183/13993003.01909 -2019%欧洲呼吸杂志% P 1901909 % V 55% N 5% X背景慢性肺疾病早产(CLD),也称为支气管肺的发育异常,是一个早产的主要结果,但微生物组在其发育过程中的作用仍不清楚。因此，我们评估了通气早产儿上、下气道细菌群落随时间的发展，并通过比较上、下气道细菌群落与粪便发现来评估肠-肺轴。最后，我们评估细菌群落是否与肺部炎症相关，以提示菌群失调。方法对通气性早产儿的上气道(鼻咽抽吸物)、下气道(气管抽吸液和支气管肺泡灌洗液)、肠道(粪便)等多个解剖部位进行连续采样。在所有样本中测量细菌DNA载量，并使用16S rRNA基因的V3-V4区域进行测序。结果55例早产儿1102例(539例鼻咽抽吸液、276例气管抽吸液、89例支气管肺泡灌洗液、198例粪便)标本中，352例(32%)扩增出适合的16S RNA基因序列。细菌载量在出生时较低，随着时间的推移迅速增加，但在所有样本类型中均与优势操作分类单位(OTUs)有关。在上、下呼吸道和肠道之间的细菌群落存在差异，婴儿的下呼吸道出现了单独的生物失调炎症过程。 Individual OTUs were associated with increased inflammatory markers.Conclusions Taken together, these findings suggest that targeted treatment of the predominant organisms, including those not routinely treated, such as Ureaplasma spp., may decrease the development of CLD in preterm-born infants.Respiratory colonisation was acquired after birth and associated with a pro-inflammatory response, suggesting an infectious process was present in babies at risk of developing chronic lung disease of prematurity (CLD), thus providing a target to reduce CLD http://bit.ly/31C27iX %U //www.qdcxjkg.com/content/erj/55/5/1901909.full.pdf