TY -的T1 -回顾前进:adherence to inhaled therapy before biologic therapy in severe asthma JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00954-2020 VL - 55 IS - 5 SP - 2000954 AU - Costello, Richard W. AU - Cushen, Breda Y1 - 2020/05/01 UR - //www.qdcxjkg.com/content/55/5/2000954.abstract N2 - For decades inhaled corticosteroids have been central to the management of asthma and are proven to be effective in maintaining symptom control, reducing exacerbations and preserving quality of life through mediation of airway inflammation. However, a small minority of patients have disease which is refractory to high dose inhaled corticosteroid (ICS) therapy and require additional oral corticosteroids to achieve acceptable control of symptoms and exacerbations. Severe asthma represents less than 10% of the total asthma population [1] but is the most serious, life-affecting and costly form of the condition [2].Inhaler adherence may inform response to asthma biologic therapy and should continue to be assessed in patients receiving these treatments https://bit.ly/2RjMBED ER -