RT期刊论文SR电子T1阻塞性睡眠呼吸暂停的治疗和血压：该表型预测的响应？系统综述和荟萃分析JF欧洲呼吸杂志JO欧洲呼吸ĴFD欧洲呼吸协会SP 1901945 DO 10.1183 / 13993003.01945-2019 VO 55 5 A1彭格，188bet官网地址Martino的F. A1 Soranna，达维德A1 Giontella，爱丽丝A1 Perger，酶联免疫吸附A1Mattaliano，帕乌拉A1施瓦茨，埃丝特艾琳A1隆巴迪，罗莱A1比洛，格热戈日A1赞邦，安东内拉A1 Steier，约尔格A1帕拉蒂，詹弗兰科A1 Minuz，彼得A1法瓦，克里斯蒂亚诺YR 2020 UL //www.qdcxjkg.com/content/55/5/1901945.abstract AB治疗阻塞性睡眠呼吸暂停（OSA）与持续气道正压（CPAP）或下颌前移装置（MADS）与（BP）血压降低相关联;然而，整体效果是有限的。该系统评价和随机对照试验（RCT）比较对BP这样的治疗效果的荟萃分析的目的是确定与特定搜索字词三个不同的数据库进行了回应谁最好treatment.The文章搜索亚组患者和选择标准。从2289篇，我们包括随机对照试验68相比CPAP或MADS与被动或主动治疗。When all the studies were pooled together, CPAP and MADs were associated with a mean BP reduction of −2.09 (95% CI −2.78– −1.40) mmHg for systolic BP and −1.92 (95% CI −2.40– −1.43) mmHg for diastolic BP and −1.27 (95% CI −2.34– −0.20) mmHg for systolic BP and −1.11 (95% CI −1.82– −0.41) mmHg for diastolic BP, respectively. The subgroups of patients who showed a greater response were those aged <60 years (systolic BP −2.93 mmHg), with uncontrolled BP at baseline (systolic BP −4.14 mmHg) and with severe oxygen desaturations (minimum arterial oxygen saturation measured by pulse oximetry <77%) at baseline (24-h systolic BP −7.57 mmHg).Although this meta-analysis shows that the expected reduction of BP by CPAP/MADs is modest, it identifies specific characteristics that may predict a pronounced benefit from CPAP in terms of BP control. These findings should be interpreted with caution; however, they are particularly important in identifying potential phenotypes associated with BP reduction in patients treated for OSA.This study identified age, blood pressure levels before treatment and hypoxic burden expressed by the minimum desaturation as potential predictors of blood pressure reduction in patients treated for obstructive sleep apnoea http://bit.ly/31LdrJA