TY - JOUR T1 - SARS-CoV-2引起的COVID-19肺炎患者死亡率的预测因子:前瞻性群组研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00524 -2020欧元六世- 55 - 5 SP - 2000524 AU - Du, Rong-Hui AU -梁,李蓉AU -杨,cheng qing AU -王,温家宝AU -曹,Tan-Ze AU - Li Ming盟——郭Guang-Yun AU - Du,胡安盟——郑chun lan盟,朱七盟——胡,明非盟- Li Xu-Yan盟——彭,彭AU -史,本研究的目的是确定新型冠状病毒SARS-CoV-2引起的COVID-19肺炎患者死亡的相关因素。所有临床和实验室参数均从2019年12月25日至2020年2月7日期间在中国湖北省武汉市肺部医院住院的COVID-19肺炎患者队列中前瞻性收集。采用单因素和多因素logistic回归分析各变量与COVID-19肺炎患者死亡风险的关系。本前瞻性研究共纳入179例COVID-19肺炎患者(男性97例，女性82例)，其中21例死亡。单因素和多因素logistic回归分析显示年龄≥65岁(OR 3.765, 95% CI 1.201-11.803;p=0.023)，预先存在的并发心脑血管疾病(or 2.464, 95%可信区间1.279-4.747;p=0.007)， CD3+CD8+ t细胞≤75细胞·μL−1 (OR 3.982, 95% CI 1.761-9.004;心肌肌钙蛋白I≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.778-9.349;p<: 0.001)与COVID-19肺炎死亡风险增加相关。 In a sex-, age- and comorbid illness-matched case–control study, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.These data showed that age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients https://bit.ly/2Rh6Nqv ER -