PT -期刊文章盟Du Rong-Hui盟——梁、Li-Rong AU - Yang, Cheng-Qing AU - Wang, Wen AU - Cao, Tan-Ze AU - Li, Ming AU - Guo, Guang-Yun AU - Du, Juan AU - Zheng, Chun-Lan AU - Zhu, Qi AU - Hu, Ming AU - Li, Xu-Yan AU - Peng, Peng AU - Shi, Huan-Zhong TI - Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study AID - 10.1183/13993003.00524-2020 DP - 2020 May 01 TA - European Respiratory Journal PG - 2000524 VI - 55 IP - 5 4099 - //www.qdcxjkg.com/content/55/5/2000524.short 4100 - //www.qdcxjkg.com/content/55/5/2000524.full SO - Eur Respir J2020 May 01; 55 AB - The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients.In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.201‒11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 1.279‒4.747; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.761‒9.004; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.778‒9.349; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case–control study, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.These data showed that age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients https://bit.ly/2Rh6Nqv