作者@article {Du2000524 = {Du, Rong-Hui和李ang, Li-Rong and Yang, Cheng-Qing and Wang, Wen and Cao, Tan-Ze and Li, Ming and Guo, Guang-Yun and Du, Juan and Zheng, Chun-Lan and Zhu, Qi and Hu, Ming and Li, Xu-Yan and Peng, Peng and Shi, Huan-Zhong}, title = {Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study}, volume = {55}, number = {5}, elocation-id = {2000524}, year = {2020}, doi = {10.1183/13993003.00524-2020}, publisher = {European Respiratory Society}, abstract = {The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients.In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age >=65 years (OR 3.765, 95\% CI 1.201-11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95\% CI 1.279-4.747; p=0.007), CD3+CD8+ T-cells <=75 cells{\textperiodcentered}μL-1 (OR 3.982, 95\% CI 1.761-9.004; p\<0.001) and cardiac troponin I >=0.05 ng{\textperiodcentered}mL-1 (OR 4.077, 95\% CI 1.778-9.349; p\<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case{\textendash}control study, CD3+CD8+ T-cells <=75 cells{\textperiodcentered}μL-1 and cardiac troponin I >=0.05 ng{\textperiodcentered}mL-1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age >=65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells <=75 cells{\textperiodcentered}μL-1 and cardiac troponin I >=0.05 ng{\textperiodcentered}mL-1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.These data showed that age >=65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells <=75 cells{\textperiodcentered}μL-1 and cardiac troponin I >=0.05 ng{\textperiodcentered}mL-1 were four risk factors predicting high mortality of COVID-19 pneumonia patients https://bit.ly/2Rh6Nqv}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/5/2000524}, eprint = {//www.qdcxjkg.com/content/55/5/2000524.full.pdf}, journal = {European Respiratory Journal} }