TY - T1的第一和复发性结节病严重感染的风险:一个瑞典基于寄存器队列研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00767 -2020欧元SP - 2000767 AU腻过Rossides盟苏珊娜Kullberg AU -安德斯·埃克伦盟丹妮拉迪盟- Johan Grunewald AU - Johan Askling AU -伊丽莎白诉Y1 - 2020/01/01 UR -阿科玛双氧水有限公司遵循严格的//www.qdcxjkg.com/content/early/2020/04/29/13993003.00767 - 2020. -抽象N2 -严重感染(SI)损害生活质量和增加成本。我们的目的是确定结节病与较高的SI是否这个变化的时代,性、自诊断,在诊断或治疗状态。我们比较个人与结节病(≥2 ICD编码在瑞典国家病人登记2003 - 2013;n = 8737)和普通人群比较器匹配10:1在年龄、性别、和住宅位置(n = 86 376)。病人诊断为2006 - 2013人分发≥1免疫抑制剂±3个月从诊断(处方药品注册)被确定。例和比较器在全国住院病人注册后感染。使用Cox和灵活的参数化模型,我们估计调整风险率和95%置信区间(aHR; CI)第一和复发SIs(新SI祝辞后30天前)。我们首先确定了895 SIs在结节病和3881年的比较器。如果是增加1.8倍的速度结节病与一般人群相比,(aHR 1.81 [95% ci 1.65, 1.98])。aHR是女性高于男性,在前两年的随访。结节病病例接受免疫抑制剂而摘要风险诊断增加了三倍左右患者的风险增加了50%。如果复发的比率高出2.8倍比比较器的情况下。SIs are more common in sarcoidosis than in the general population, particularly during the first few years after diagnosis. Patients who need immunosuppressant treatment around diagnosis are twice as likely to develop a serious infection than those who do not.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Rossides has nothing to disclose.Conflict of interest: Dr. Kullberg has nothing to disclose.Conflict of interest: Dr. Eklund has nothing to disclose.Conflict of interest: Dr. Di Giuseppe has nothing to disclose.Conflict of interest: Dr. Grunewald reports grants from Swedish Heart-Lung Foundation (Hjärt-Lungfonden), during the conduct of the study.Conflict of interest: Dr. Askling has nothing to disclose.Conflict of interest: Dr. Arkema reports grants from Swedish Heart-Lung Foundation (Hjärt-Lungfonden), during the conduct of the study. ER -