% 0期刊文章%裴绮Tiew %范妮围San Ko % Sze Lei彭日成%一个斯里兰卡Anusha马塔%杨叶Sio %一个猫白尾海雕Poh %一个肯尼耶稣基督Lau %迈克尔Mac Aogain % Tavleen Kaur Jaggi % Fransiskus Xaverius伊凡%尼古拉斯·e·高提耶%一个彰田% Daniela i Drautz-Moses % Huiying徐%一个圆子Siyue Koh %大卫蜀昌回族% %约翰·奥古斯汀T Arputhan Abisheganaden % Stephan c·舒斯特尔%福蒂姆咀嚼% Sanjay h . Chotirmall % T环境真菌敏化作用的同事与贫穷的临床结果在慢性阻塞性肺病% D J 2020% R 10.1183/13993003.00418 -2020%欧洲呼吸杂志% P 2000418 % X引入对曲霉菌等真菌的过敏敏化作用相关的不良临床结果在哮喘、支气管扩张和囊性纤维化,然而,在慢性阻塞性肺病的临床意义尚不清楚。方法稳定的慢性阻塞性肺病患者(n = 446)和十几控制(n = 51)前瞻性招募在三个国家(新加坡、马来西亚和香港)和筛选综合过敏原面板包括屋尘螨、花粉、蟑螂和真菌。第一次使用宏基因组方法,我们评估户外和室内环境过敏原暴露在慢性阻塞性肺病。我们确定室外空气的重要真菌和开发特殊ige化验对顶部可耕种的真菌,敏化作用的反应与慢性阻塞性肺病的结果。室内空气和表面过敏原被宏基因组前瞻性评估房屋的n = 11 COPD患者和临床结果。结果高频范围广泛的过敏原的敏化作用发生在慢性阻塞性肺病。真菌的敏化作用的同事频繁发作,无监督聚类揭示了一个“高度敏感真菌主要“亚群体展示重要的症状,发作频繁,肺功能不佳。室外和室内环境作为重要的真菌水库过敏原暴露在慢性阻塞性肺病,促进一个敏化作用对室外空气真菌的回应。室内高真菌过敏原(家)环境与更大的慢性阻塞性肺病的症状和肺功能较差的重要性说明环境因素在慢性阻塞性肺病的临床结果。结论真菌在慢性阻塞性肺病和同事敏化作用是普遍和频繁发作代表一个潜在的治疗特点。室外和室内(家)环境代表真菌变应原暴露的一个主要来源,适合干预,在慢性阻塞性肺病“敏感”。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。这些生产过程完成后,作者已经批准结果证明,本文将最新一期的ERJ在线。 Please open or download the PDF to view this article.Conflict of interest: Dr. Tiew has nothing to disclose.Conflict of interest: Dr. Ko has nothing to disclose.Conflict of interest: Dr. Pang has nothing to disclose.Conflict of interest: Dr. Matta has nothing to disclose.Conflict of interest: Dr. Sio has nothing to disclose.Conflict of interest: Dr. Poh has nothing to disclose.Conflict of interest: Dr. Lau has nothing to disclose.Conflict of interest: Dr. Mac Aogain has nothing to disclose.Conflict of interest: Dr. Jaggi has nothing to disclose.Conflict of interest: Dr. Ivan has nothing to disclose.Conflict of interest: Dr. Gaultier has nothing to disclose.Conflict of interest: Dr. Uchida has nothing to disclose.Conflict of interest: Dr. Drautz-Moses has nothing to disclose.Conflict of interest: Dr. Xu has nothing to disclose.Conflict of interest: Dr. Koh has nothing to disclose.Conflict of interest: Dr. Shu has nothing to disclose.Conflict of interest: Dr. Tee has nothing to disclose.Conflict of interest: Dr. Abisheganaden has nothing to disclose.Conflict of interest: Dr. Schuster has nothing to disclose.Conflict of interest: Dr. Chew has nothing to disclose.Conflict of interest: Dr. H Chotirmall has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2020/04/20/13993003.00418-2020.full.pdf