@article {Tiew2000418,作者= {Tiew,裴伊Ko,范妮围圣,彭日成Sze Lei和马塔,斯里兰卡Anusha Sio,杨叶和Poh茂白尾海雕和刘,肯尼耶稣基督和Mac Aog{\ '},偷窃{\ '}l和Jaggi Tavleen考尔和伊万,Fransiskus Xaverius高提耶,尼古拉斯·e·和田彰Drautz-Moses,丹妮拉我和徐,Huiying和Koh Siyue圆子和回族,大卫·蜀昌和三通,奥古斯汀和Abisheganaden约翰Arputhan和舒斯特尔,Stephan c和咀嚼,福蒂姆和Chotirmall,Sanjay H.}，标题={环境真菌致敏与COPD较差临床结果相关}，位置-id ={2000418}，年份= {2020}，doi ={10.1183/13993003.00418-2020}，出版商={欧洲呼吸学会}，摘要={导文对真菌(如Aspergillus)的过敏致敏与哮喘、支气管扩张和囊性纤维化的不良临床结果相关，但与COPD的临床相关性尚不清楚。188bet官网地址方法前瞻性地在三个国家(新加坡、马来西亚和香港)招募稳定期COPD患者(n=446)和非患病对照组(n=51)，并对包括室内尘螨、花粉、蟑螂和真菌在内的综合过敏原面板进行筛选。我们首次使用宏基因组学方法评估COPD的室外和室内环境过敏原暴露。我们鉴定了室外空气中的关键真菌，并针对顶级可培养真菌开发了特异性ige检测，将致敏反应与COPD结果联系起来。通过宏基因组学对n=11名COPD患者家中的室内空气和表面过敏原进行了前瞻性评估，并与临床结果相关。结果COPD患者对多种变应原的高频率致敏。真菌致敏与频繁的加重有关，并且，无监督聚类揭示了一个高度致敏的真菌优势亚组，表现出显著的症状学，频繁的加重和肺功能差。室外和室内环境是慢性阻塞性肺病真菌过敏原暴露的重要储存库，并促进对室外空气真菌的致敏反应。具有高真菌过敏原的室内(家庭)环境与COPD症状加重和肺功能较差有关，说明环境暴露对COPD临床结果的重要性。结论真菌致敏在COPD中普遍存在，并与频繁的加重有关，这是一种潜在的可治疗特征。在{\textquotedblleft}致敏的{\textquotedblright} COPD中，室外和室内(家庭)环境是真菌过敏原暴露的关键来源，可进行干预。这篇手稿最近已被《欧洲呼吸杂志》接受发表。在我们的制作团队进行编辑和排版之前，它以其可接受的形式在这里发布。 After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Tiew has nothing to disclose.Conflict of interest: Dr. Ko has nothing to disclose.Conflict of interest: Dr. Pang has nothing to disclose.Conflict of interest: Dr. Matta has nothing to disclose.Conflict of interest: Dr. Sio has nothing to disclose.Conflict of interest: Dr. Poh has nothing to disclose.Conflict of interest: Dr. Lau has nothing to disclose.Conflict of interest: Dr. Mac Aogain has nothing to disclose.Conflict of interest: Dr. Jaggi has nothing to disclose.Conflict of interest: Dr. Ivan has nothing to disclose.Conflict of interest: Dr. Gaultier has nothing to disclose.Conflict of interest: Dr. Uchida has nothing to disclose.Conflict of interest: Dr. Drautz-Moses has nothing to disclose.Conflict of interest: Dr. Xu has nothing to disclose.Conflict of interest: Dr. Koh has nothing to disclose.Conflict of interest: Dr. Shu has nothing to disclose.Conflict of interest: Dr. Tee has nothing to disclose.Conflict of interest: Dr. Abisheganaden has nothing to disclose.Conflict of interest: Dr. Schuster has nothing to disclose.Conflict of interest: Dr. Chew has nothing to disclose.Conflict of interest: Dr. H Chotirmall has nothing to disclose.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2020/04/20/13993003.00418-2020}, eprint = {//www.qdcxjkg.com/content/early/2020/04/20/13993003.00418-2020.full.pdf}, journal = {European Respiratory Journal} }