％0期刊文章％A Ali，Md。Khadem％A Kim，Richard Y.％A Brown，Alexandra C.％A Mayall，Jemma R.％A Karim，Rafia a Karim，Rafia％A Pinkerton，James W.％liu，Gang％Martin，Kristy L.％A Starkey，Malcolm R.％A Pillar，Amber L.％Donovan，Chantal％A Pathinayake，Prabuddha S.％A Carroll，Olivia R.％A trinder，Debbie％A TAY，HOCK L，HOCK L，HOCK L。％a badi，yusef E.％a kermani，nazanin Z.％a guo，yi-ke％a aryal，ritambhara％a mumby，sharon％a pavlidis，stelios％a adcock，ian M.Xenaki，Dikaia％A Oliver，Brian G.％A Holliday，Elizabeth G.％A Foster，Paul S.％A Wark，Peter A.％A.％Johnstone，Daniel M.％A Milward，Elizabeth A.％A.％A Hansbro，Hansbro，Hansbro，Philip M.％A Horvat，Jay C.％T对于肺铁水平和调节在哮喘的发病机理和严重程度中的至关重要作用2020％R 10.1183/13993003.01340-2019％J欧洲呼吸道Journal j欧洲呼吸杂志％p 1901340％v 1901340％v 55％v 55％N N4％X积累证据突出了铁调节与呼吸道疾病之间的联系。在这里，我们评估了临床和实验性哮喘中铁水平与调节反应之间的关系。我们表明，严重或轻度 - 温度哮喘患者的支气管肺泡灌洗（BAL）上清液中无细胞的铁水平会降低1 s（FEV1）的体积。相反，在这些患者中，BAL的铁细胞数量增加，而FEV1/强制生命力（FVC）比率较低。哮喘中，铁隔离分子二价金属转运蛋白1（DMT1）和转铁蛋白受体1（TFR1）的气道组织表达增加，TFR1的表达与肺功能的降低和增加的肺功能（T2）相关。此外，与人类疾病类似的气道组织中TFR1的增强TFR1的表达相关的室内粉尘螨（HDM）诱导的实验性哮喘模型增加了肺铁水平。 We show that macrophages are the predominant source of increased Tfr1 and Tfr1+ macrophages have increased Il13 expression. We also show that increased iron levels induce increased pro-inflammatory cytokine and/or extracellular matrix (ECM) responses in human airway smooth muscle (ASM) cells and fibroblasts ex vivo and induce key features of asthma in vivo, including airway hyper-responsiveness (AHR) and fibrosis, and T2 inflammatory responses.Together these complementary clinical and experimental data highlight the importance of altered pulmonary iron levels and regulation in asthma, and the need for a greater focus on the role and potential therapeutic targeting of iron in the pathogenesis and severity of disease.The relationship between iron and the pathogenesis of asthma remains unclear. Here it is shown for the first time that altered iron responses are a key feature of clinical and experimental asthma and may play important roles in disease. http://bit.ly/36JKajt %U //www.qdcxjkg.com/content/erj/55/4/1901340.full.pdf