TY - JOUR T1 -早期生活抗生素的使用和哮喘和湿疹的风险:结果不一致的双胞胎研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.02021 -2019欧元六世- 55 - 4 SP - 1902021 AU -懒汉,爱丽丝硕士非盟-酿造,布朗温k . AU - Vijverberg Susanne J.H.盟——凯特,尚塔尔J.A.R. AU -隆戈,克里斯蒂娜盟——Pijnenburg Marielle w . AU - van Beijsterveldt吐司传情专家C.E.M. AU -多兰,康纳诉AU -巴特尔斯Meike AU - Magnusson,帕特里克AU -列支敦士登,保罗AU -锣,通盟——Koppelman杰拉德h . AU - Almqvist,卡塔琳娜·奥- Boomsma, Dorret I. AU - Maitland-van der Zee, Anke H. Y1 - 2020/04/01 UR - //www.qdcxjkg.com/content/55/4/1902021.摘要N2 -基本原理早期抗生素的使用与特应性疾病的发展有关，但病因尚不清楚。为了阐明病因，我们使用不一致的双胞胎设计来控制遗传和环境混杂。方法我们对荷兰3-10岁的双胞胎进行了回顾性队列研究(NTR, n= 35365)，并对瑞典9岁的儿童和青少年双胞胎进行了重复研究(CATSS, n=7916)。抗生素使用记录0-2岁。父母在3-12岁时报告了医生诊断的哮喘和湿疹。个人包括在不匹配的分析和疾病不一致的双胞胎对的同卵双胞胎控制分析。结果早期抗生素使用与哮喘风险增加相关(NTR或1.34,95% CI 1.28-1.41;湿疹(NTR或1.08,95% CI 1.03-1.13;不匹配分析的CATSS或1.07,95% CI 1.01-1.14)。 Co-twin analyses in monozygotic and dizygotic twin pairs showed similar results for asthma (NTR OR 1.54, 95% CI 1.20–1.98; CATSS OR 2.00, 95% CI 1.28–3.13), but opposing results for eczema in the NTR (OR 0.99, 95% CI 0.80–1.25) and the CATSS (OR 1.67, 95% CI 1.12–2.49). The risk of asthma increased for antibiotics prescribed for respiratory infections (CATSS OR 1.45, 95% CI 1.34–1.56), but not for antibiotics commonly used for urinary tract/skin infections (CATSS OR 1.02, 95% CI 0.88–1.17).Conclusion Children exposed to early-life antibiotic use, particularly prescribed for respiratory infections, may be at higher risk of asthma. This risk can still be observed when correcting for genetic and environmental factors. Our results could not elucidate whether the relationship between early-life antibiotic use and eczema is confounded by familial and genetic factors.Large twin studies show that antibiotics in early life are associated with risk of asthma, regardless of familial environment and genetics, and possibly due to early infections. Risks and benefits of antibiotics use in infants should be considered. http://bit.ly/372Qu5A ER -