TY - T1的迟发性的“急性纤维素性肺炎和组织”损害长期移植肺功能和生存JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02292 -2019欧元SP - 1902292 AU -阿诺Vanstapel盟Stijn大肠Verleden盟Birgit Weynand AU -埃里克Verbeken盟Laurens De Sadeleer盟-巴特·m·Vanaudenaerde AU -基尔特•m . Verleden盟-罗宾Vos AU -鲁汶肺移植组Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/04/20/13993003.02292 - 2019. -抽象N2 -急性纤维蛋白的背景和组织相关肺炎(AFOP)肺移植后肺功能迅速下降。然而,与慢性肺部同种异体移植物功能障碍(复合)仍不清楚。我们调查之间的关系检测AFOP异体肺活检的临床重要的端点。方法:我们回顾了从468年异体肺活检病人肺移植医院鲁汶大学(2011 - 2017)。AFOP被归类为最近诊断为早期(≤90天移植后)或最近诊断为晚期(在移植后90天);与CLAD-free生存,移植物存活率,供体特异性抗体,气道嗜酸性粒细胞和血液。结果早期和晚期AFOP中检测出24(5%)和30例(6%)患者,分别。CLAD-free生存显著低于AFOP晚期患者(平均生存2.42 y,术中;0.0001)相比,患者早期或没有AFOP特别是与发展相关限制性的同种异体移植物综合征(or: 28.57;CI(11.34 - -67.88),术中;0.0001)。同样,移植物存活率显著低于AFOP晚期患者(平均生存4.39 y,术中;0.0001)相比,患者早期AFOP或没有AFOP。晚AFOP而且与循环供体特异性抗体的检测(OR: 4.75, CI [2.17 - -10.60], p = 0.0004)相比,患者早期的或没有AFOP; and elevated airway and blood eosinophilia (p=0.043 and p=0.045, respectively) compared to early AFOP patients.Conclusions Late new-onset AFOP is associated with a worse prognosis and high risk of CLAD development, specifically restrictive allograft syndrome. Our findings indicate that late new-onset AFOP might play a role in the early pathogenesis of restrictive allograft syndrome.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Vanstapel has nothing to disclose.Conflict of interest: Dr. Verleden has nothing to disclose.Conflict of interest: Dr. Weynand has nothing to disclose.Conflict of interest: Dr. Verbeken has nothing to disclose.Conflict of interest: Dr. De Sadeleer has nothing to disclose.Conflict of interest: Dr. Vanaudenaerde has nothing to disclose.Conflict of interest: Dr. Verleden has nothing to disclose.Conflict of interest: Dr. Vos has nothing to disclose. ER -