RT期刊文章SR电子T1自身免疫性疾病的主要遗传因素与自身抗体的存在在过敏性肺炎摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1901380 10.1183/13993003.01380 -2019 A1 Ivette Buendia-Roldan A1局长Mayra Mejia A1 Jorge Luis Santiago-Ruiz A1 Gloria Perez-Rubio A1 Rojas-Serrano A1恩里克Am188bet官网地址brocio-Ortiz A1吉奥瓦尼Benitez-Valdez A1莫伊塞斯塞尔曼A1 Falfan-Valencia兰姆克年2020 UL //www.qdcxjkg.com/content/early/2020/04/20/13993003.01380 AB - 2019. -抽象背景过敏性肺炎(惠普)是一种免疫介导性疾病引发的感染人群的暴露于有机粒子。据报道,一亚组病人与惠普发展自身抗体有或没有临床表现的自身免疫性疾病。然而,参与这个过程的机制和自身抗体在临床过程惠普的影响是未知的。我们评估患者HLA二类等位基因之间的联系和惠普,没有自身抗体。方法一百七十马力患者包括在内。我们分析了抗核抗体的存在,类风湿因子,anti-SSA / Ro anti-SSB /洛杉矶,anti-CCP时诊断。此外,在病人的一个子集,我们评估反sci - 70, ANCA, anti-DNA。HLA打字是由PCR-SSP高分辨率模式,包括HLA-DRB1和HLA-DQB1位点。采用Epi-Info v7和SPSSv20执行统计分析。60 HP病人结果显示血清自身抗体(HPAbs +),和110马力的病人没有(HPAbs−)。等位基因的频率HLA-DRB1 * 03:01 HPAbs +组显著增加(分别为10.8%和0.45%; OR=30.14, 95%CI 3.83–237.1; p=1.65E-04 after Bonferroni's correction). Likewise, we found that the haplotype DRB1*03:01-DQB1*02:01, which is part of the 8.1 ancestral haplotype, a major genetic determinant of autoimmune diseases confers significant risk to develop autoantibodies (OR=19.23, 95%CI 2.37–155.9; p=0.0088 after Bonferroni's correction). Also, the HLA-DRB1*03:01 allele was associated with higher mortality in patients with HP (adjusted OR=5.9, 95%IC 1.05–33.05; p=0.043).Conclusions A subset of HP patients presents circulating autoantibodies and higher mortality, that are associated with some alleles of 8.1 ancestral haplotype.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Santiago-Ruiz has nothing to disclose.Conflict of interest: Dr. Pérez-Rubio has nothing to disclose.Conflict of interest: Dr. Mejía has nothing to disclose.Conflict of interest: Dr. Rojas-Serrano has nothing to disclose.Conflict of interest: Dr. Ambrocio-Ortiz has nothing to disclose.Conflict of interest: Dr. Benítez-Valdez has nothing to disclose.Conflict of interest: Dr. Selman has nothing to disclose.Conflict of interest: Dr. Buendía-Roldán has nothing to disclose.Conflict of interest: Dr. Falfán-Valencia has nothing to disclose.