RT期刊论文SR电子T1幼儿呼吸道发病率和前早产儿使用抗生素：一种基于人口的初级保健队列研究JF欧洲呼吸杂志JO欧元呼吸杂志FD欧洲呼吸学会SP 2000202 DO 10.1183 / 13993003.00202-2020 A1谭，188bet官网地址新A1 Szatkowski，丽莎A1摩，威廉A1 Fiaschi，琳达A1 McKeever，特里西娅A1吉布森，杰克·夏基A1，唐YR 2020 UL //www.qdcxjkg.com/content/early/2020/04/08/13993003.00202-2020.abstract AB背景全球范围内，支气管肺发育不良（BPD）继续早产儿增加。最近的研究探索后续幼儿呼吸道发病率已经很小或专注于医院admissions.Primary目标检查呼吸道感染初期诊疗（RTI）的儿童早期率，下呼吸道感染（LRTI），喘鸣和抗生素处方（ABX Px的）的前早产儿和足月儿。Secondary aim: examine differences between preterm infants discharged home with or without oxygen.Methods Retrospective cohort study using linked electronic primary care and hospital databases of children born between 1997 and 2014. We included 253 677 eligible children, with 1666 born preterm <32 weeks' gestation, followed up from primary care registration to age 5 years. Adjusted incidence rate ratios (aIRR) were calculated.Results Ex-preterm infants had higher rates of morbidity across all respiratory outcomes. After adjusting for confounders, aIRRs for RTI (1.37, 95% CI 1.33–1.42), LRTI (2.79, 95% CI 2.59–3.01), wheeze (3.05, 95% CI 2.64–3.52) and Abx Px (1.49, 95% CI 1.44–1.55) were higher for ex-preterm infants. Ex-preterm infants discharged home on oxygen had significantly greater morbidity across all respiratory diagnoses and Abx Px compared to those without home oxygen. The highest rates of respiratory morbidity were observed in children from the most deprived socioeconomic groups.Conclusion Ex-preterm infants, particularly those with BPD requiring home oxygen, have significant respiratory morbidity and antibiotic prescriptions in early childhood. With the increasing prevalence of BPD, further research should focus on strategies to reduce the burden of respiratory morbidity in these high-risk infants after hospital discharge.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Tan has nothing to disclose.Conflict of interest: Dr. Szatkowski has nothing to disclose.Conflict of interest: Dr. Moreton has nothing to disclose.Conflict of interest: Dr. Fiaschi has nothing to disclose.Conflict of interest: Dr. McKeever has nothing to disclose.Conflict of interest: Dr. Gibson has nothing to disclose.Conflict of interest: Dr. Sharkey has nothing to disclose.