RT期刊文章SR电子T1与临床表型细胞白细胞介素- 6和协会的来源和结果在肺动脉高血压摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1901761 10.1183/13993003.01761 -2019签证官55是4 A1辛普森,凯瑟琳·e·陈A1,珍妮y A1 Damico,雷切尔·l·A1哈桑,Paul m . A1马丁,丽莎·J·杨A1,小君A1 Nies,梅勒妮A1格里菲斯,梅根A1 Vaidya,188bet官网地址 r . Dhananjay A1 Brandal,斯蒂芬妮A1 Pauciulo迈克尔·w·鲁兹A1凯蒂·a·A1科尔曼,安娜·w·奥斯汀A1埃里克·d·A1常春藤,邓巴d A1尼科尔斯,威廉·c·A1埃弗雷特,艾伦·d·年2020 UL //www.qdcxjkg.com/content/55/4/1901761.abstract AB的促炎细胞因子白介素6 (IL)与结果有关小肺动脉高血压(PAH)军团主要由患者严重特发性肺动脉高压(IPAH)。目前还不清楚IL-6是危重症的标志还是肺血管重建的机械生物标志物。我们假设IL-6是由肺血管细胞产生的，并试图在一个大的PAH队列中探索IL-6与表型和不同亚型之间的关系。检测肺动脉平滑肌细胞(PASMCs)和内皮细胞(PAECs)中IL-6蛋白和基因表达水平。2017年测定了代表每个PAH亚组的特征良好的多环芳烃受试者的血清IL-6。使用回归模型分析IL-6水平、临床变量和死亡率之间的关系。在PAH中，PASMCs产生的IL-6蛋白和基因表达水平明显高于PAECs (p<0.001)，而对照组中IL-6在细胞类型上没有差异。血清IL-6在肺动脉高压中最高，与门脉高压和结缔组织疾病(CTD-PAH)有关。在多变量建模中，血清IL-6与整个队列的生存率相关(危险比1.22,95% CI 1.88 - 1.38; p<0.01) and in IPAH, but not in CTD-PAH. IL-6 remained associated with survival in low-risk subgroups of subjects with mild disease.IL-6 is released from PASMCs, and circulating IL-6 is associated with specific clinical phenotypes and outcomes in various PAH subgroups, including subjects with less severe disease. IL-6 is a mechanistic biomarker, and thus a potential therapeutic target, in certain PAH subgroups.Circulating IL-6, a pro-inflammatory cytokine produced by pulmonary arterial smooth muscle cells, is significantly associated with clinical phenotypes and survival in pulmonary arterial hypertension, which may guide individualised disease management https://bit.ly/3awkkSz