TY - T1的细胞来源的白细胞介素- 6和协会与临床表型和结果在肺动脉高血压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01761 -2019欧元六世- 55 - 4 SP - 1901761 AU -辛普森,凯瑟琳e . AU -陈,珍妮y . AU - Damico,雷切尔·l . AU -哈桑,Paul m . AU -马丁,丽莎J . AU -杨,君非盟-算,梅勒妮AU -格里菲斯,梅根盟——Vaidya r . Dhananjay AU - Brandal,斯蒂芬妮盟——Pauciulo凯蒂·a·迈克尔·鲁兹w . AU - AU -科尔曼,安娜·w . AU -奥斯汀,埃里克·d . AU -常春藤,邓巴d . AU -尼科尔斯,威廉·c·AU -埃弗雷特,艾伦·d·Y1 - 2020/04/01 UR - //www.qdcxjkg.com/content/55/4/1901761.abstract N2 -促炎症细胞因子白介素6 (IL)与结果有关小肺动脉高血压(PAH)军团主要由患者严重特发性肺动脉高压(IPAH)。目前还不清楚IL-6是危重症的标志还是肺血管重建的机械生物标志物。我们假设IL-6是由肺血管细胞产生的，并试图在一个大的PAH队列中探索IL-6与表型和不同亚型之间的关系。检测肺动脉平滑肌细胞(PASMCs)和内皮细胞(PAECs)中IL-6蛋白和基因表达水平。2017年测定了代表每个PAH亚组的特征良好的多环芳烃受试者的血清IL-6。使用回归模型分析IL-6水平、临床变量和死亡率之间的关系。PAH中PASMCs产生的IL-6蛋白和基因表达水平明显高于PAECs (p<0.001)，而对照组中IL-6在细胞类型上没有差异。血清IL-6在肺动脉高压中最高，与门脉高压和结缔组织疾病(CTD-PAH)有关。在多变量建模中，血清IL-6与整个队列的生存率相关(危险比1.22,95% CI 1.88 - 1.38; p<0.01) and in IPAH, but not in CTD-PAH. IL-6 remained associated with survival in low-risk subgroups of subjects with mild disease.IL-6 is released from PASMCs, and circulating IL-6 is associated with specific clinical phenotypes and outcomes in various PAH subgroups, including subjects with less severe disease. IL-6 is a mechanistic biomarker, and thus a potential therapeutic target, in certain PAH subgroups.Circulating IL-6, a pro-inflammatory cytokine produced by pulmonary arterial smooth muscle cells, is significantly associated with clinical phenotypes and survival in pulmonary arterial hypertension, which may guide individualised disease management https://bit.ly/3awkkSz ER -