PT -期刊文章AU -辛普森,凯瑟琳e . AU -陈,珍妮y . AU - Damico,雷切尔·l . AU -哈桑,Paul m . AU -马丁,丽莎·j . AU -杨,君非盟- Nies,梅勒妮AU -格里菲斯,梅根盟——Vaidya r . Dhananjay AU - Brandal,斯蒂芬妮AU - Pauciulo,迈克尔·w . AU -鲁兹,凯蒂·a . AU -科尔曼,安娜·w . AU -奥斯汀,埃里克·d . AU -常春藤,邓巴d . AU -尼科尔斯,威廉·c·AU -埃弗雷特,艾伦·d·TI -细胞白细胞介素- 6和协会的来源与肺动脉高血压的临床表型和结果援助- 10.1183/13993003.01761 -2019 DP - 2020年4月01 TA -欧洲呼吸杂志》第六PG - 1901761 - 55 IP - 4 4099 - //www.qdcxjkg.com/content/55/4/1901761.short 4100 - //www.qdcxjkg.com/content/55/4/1901761.full所以欧元和J2020 4月01;55ab -促炎细胞因子白介素(IL)-6已被证实与以重度特发性肺动脉高压(IPAH)患者为主的小肺动脉高压(PAH)组的预后相关。目前还不清楚IL-6是危重症的标志还是肺血管重建的机械生物标志物。我们假设IL-6是由肺血管细胞产生的，并试图在一个大的PAH队列中探索IL-6与表型和不同亚型之间的关系。检测肺动脉平滑肌细胞(PASMCs)和内皮细胞(PAECs)中IL-6蛋白和基因表达水平。2017年测定了代表每个PAH亚组的特征良好的多环芳烃受试者的血清IL-6。使用回归模型分析IL-6水平、临床变量和死亡率之间的关系。PAH中PASMCs产生的IL-6蛋白和基因表达水平明显高于PAECs (p<0.001)，而对照组中IL-6在细胞类型上没有差异。血清IL-6在肺动脉高压中最高，与门脉高压和结缔组织疾病(CTD-PAH)有关。 In multivariable modelling, serum IL-6 was associated with survival in the overall cohort (hazard ratio 1.22, 95% CI 1.08–1.38; p<0.01) and in IPAH, but not in CTD-PAH. IL-6 remained associated with survival in low-risk subgroups of subjects with mild disease.IL-6 is released from PASMCs, and circulating IL-6 is associated with specific clinical phenotypes and outcomes in various PAH subgroups, including subjects with less severe disease. IL-6 is a mechanistic biomarker, and thus a potential therapeutic target, in certain PAH subgroups.Circulating IL-6, a pro-inflammatory cytokine produced by pulmonary arterial smooth muscle cells, is significantly associated with clinical phenotypes and survival in pulmonary arterial hypertension, which may guide individualised disease management https://bit.ly/3awkkSz