Ty-jour t1 - 抗核抗体和社区住宅成年人的亚临床间质性肺病：MESA学习JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003.02262-2019 VL - 55 IS - 4 SP - 1902262 Au - Bernstein, Elana J. AU - Austin, John H.M. AU - Kawut, Steven M. AU - Raghu, Ganesh AU - Hoffman, Eric A. AU - Newell, John D. AU - Watts, Jubal R. AU - Nath, P. Hrudaya AU - Sonavane, Sushilkumar K. AU - Barr, R. Graham AU - Lederer, David J. Y1 - 2020/04/01 UR - //www.qdcxjkg.com/content/55/4/1902262.abstract N2 - The presence of a systemic autoimmune rheumatic disease (ARD) is a well-known risk factor for interstitial lung disease (ILD). For example, 33% of adults with rheumatoid arthritis (RA) have subclinical ILD [1]. Higher serum levels of IgM rheumatoid factor (RF), IgA RF, and anti-cyclic citrullinated peptide antibody 2 are associated with subclinical ILD in community-dwelling adults [2]. It is unknown whether this relationship between autoimmunity and subclinical ILD is limited to RA-related autoantibodies, or extends more broadly to other epitopes. High attenuation areas (HAA) and interstitial lung abnormalities (ILA) are validated quantitative and qualitative subclinical ILD phenotypes, respectively. In community-dwelling adults, greater HAA is associated with reduced forced vital capacity, reduced exercise capacity, elevated serum levels of matrix metalloproteinase-7 and interleukin-6, higher prevalence of ILA on computed tomography (CT) scans of the chest, higher all-cause mortality rate, and an increased risk of developing clinically evident ILD and ILD-specific mortality at 12-year follow-up [3, 4]. ILA has been associated with all-cause mortality in four different longitudinal cohorts [5]. The purpose of this study was to examine the association between antinuclear antibody (ANA) and both HAA and ILA in community-dwelling adults enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA).Antinuclear antibodies are associated with subclinical interstitial lung disease in community-dwelling adults enrolled in the Multi-Ethnic Study of Atherosclerosis http://bit.ly/2FIEJpSThe authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at www.mesa-nhlbi.org ER -