PT - 杂志AU - 麦克马蒙，德里克B. Au - Carey，Ryan M. Au - Kohanski，Michael A. Au - Tong，Charles C.L.Au - Papagiannopoulos，Peter Au - Adappa，Nithin D. Au - Palmer，James N. Au - Lee，Robert J.TI - 神经肽的分泌和人类气道腺体浆液中的分泌和炎症调节 - 10.1183 / 13993003.01386-2019 DP - 20204月1日TA - 欧洲呼吸期刊PG - 1901386 VI - 55 IP - 4 4099 - //www.qdcxjkg.com/content/55/4/1901386.short 4100 - //www.qdcxjkg.com/content/ 55/4/1901386.full so - 欧元reshir J2020 4月01日;55 AB - Airway粘膜腺体浆液细胞是囊性纤维化跨膜电导调节器（CFTR）的表达位点，对于导通气道的流体分泌很重要。为了阐明神经肽如何调节浆液细胞，我们测试了人鼻鼻甲浆液细胞分泌碳酸氢盐（HCO3-），对于粘膜聚合和抗微生物肽功能重要，在露营升高的血管活性肠肽（VIP）和如果这需要CFTR，则在刺激期间。用VIP刺激的浆液细胞表现出〜10-20％的阵营依赖性降低细胞体积和细胞内pH（PHI）的〜0.15单位降低，分别反映了Cl-和HCO3分泌的激活。HCO3分泌直接依赖于CFTR，并且在CF患者中不存在于细胞中。相反，神经肽Y（npy）降低的vip诱发阵营增加，CFTR活化和CL- / HCO3分泌。初级浆液细胞的培养在维持浆液表型的模型中，确认了vip和npy的活化和抑制效果，液体和hco3分泌。此外，VIP增强了分泌物的抗微生物肽分泌和分泌物的抗微生物功效，而NPE降低了抗菌疗效。 In contrast, NPY enhanced cytokine release while VIP reduced cytokine release through a mechanism requiring CFTR. As levels of VIP and NPY are up-regulated in diseases like allergy, asthma, and chronic rhinosinusitis, the balance of these two peptides in the airway may control mucus rheology and inflammatory responses in serous cells. Furthermore, the loss of CFTR conductance in serous cells may contribute to CF pathophysiology by increasing serous cells inflammatory responses in addition to directly impairing Cl− and HCO3− secretion.VIP and NPY are neuropeptides up-regulated in allergy and asthma, respectively, which inversely regulate CFTR-dependent secretion and inflammation in airway submucosal gland serous cells, and which secrete much of the fluid that lines conducting airways http://bit.ly/2FWNT29