TY - T1的棱镜的全球意义:how data from low- and middle-income countries link physiology to inflammation JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00354-2020 VL - 55 IS - 4 SP - 2000354 AU - Wijnant, Sara R.A. AU - Lahousse, Lies AU - Brusselle, Guy G. Y1 - 2020/04/01 UR - //www.qdcxjkg.com/content/55/4/2000354.abstract N2 - In a recent paper published in the European Respiratory Journal, we studied the characteristics, trajectory and mortality of subjects with Preserved Ratio Impaired Spirometry (PRISm) in the Rotterdam Study, a prospective population-based cohort study in the Netherlands, a high-income country (HIC) [1]. In an elegant letter to the editor, P. Jackson and T. Siddharthan correctly argue that clinical research on PRISm has been limited so far in its potential to grasp a representative sample of the world population, with marked underrepresentation of studies in low- and middle-income countries (LMICs). Despite potential differences in risk factors, they suggest that systemic inflammation plays a key role in the pathogenesis of PRISm in both HIC and LMICs.Subjects with PRISm represent a heterogeneous population encompassing distinct phenotypes with distinct risk factors. A spectrum of mechanisms and risk factors contribute to varying degrees to the pathogenesis of PRISm in different populations. http://bit.ly/2TkHJjK ER -