PT -期刊文章盟Samu Kainulainen AU -布雷特首领盟亨利Korkalainen AU -阿里Oksenberg盟Akseli Leino AU -厄纳s Arnardottir盟Antti Kulkas AU -萨米Myllymaa盟Juha Toyras盟Timo Leppanen TI -严重稀释增加精神运动警觉基于任务的平均反应时间和失误的阻塞性睡眠呼吸暂停患者援助- 10.1183/13993003.01849 -2019 DP - 2020年4月01 TA -欧洲呼吸杂志》第六PG - 1901849 - 55 IP - 4 4099 - //www.qdcxjkg.com/content/55/4/1901849.short 4100 - //www.qdcxjkg.com/content/55/4/1901849.full所以欧元和J2020 4月01;55 AB -当前诊断参数估计阻塞性睡眠呼吸暂停(OSA)严重程度有一个贫穷的阻塞性睡眠呼吸暂停综合症患者的精神运动警觉。因此,我们旨在调查呼吸暂停的严重程度如何,hypopnoeas和间歇性低氧血与受损的警惕。我们回顾性分析了I型多导睡眠图数据和相应的精神运动警觉任务(pvt)的743名连续阻塞性睡眠呼吸暂停综合症患者(apnoea-hypopnoea指数(AHI)≥5事件·h−1)。传统诊断参数(例如:你好,血氧饱和度下降指数(ODI))和新颖的参数(如减饱和程度和梗阻程度)合并呼吸暂停时间和hypopnoeas以及稀释被评估的深度和持续时间。患者分为四分位数基于PVT的结果变量。属于表现最差的四分位数的可能性进行评估。对所有PVT分析使用二项逻辑回归结果变量。相对平均减饱和深度增加10%的几率升高(术ORrange 1.20 - -1.37, 0.05)的长期均值和中位数反应时间以及失效数增加。同样,增加稀释程度(术ORrange 1.26 - -1.52, 0.05)与长期平均反应时间有关。 Female sex (ORrange 2.21–6.02, p<0.01), Epworth Sleepiness Scale score (ORrange 1.05–1.07, p<0.01) and older age (ORrange 1.01–1.05, p<0.05) were significant risk factors in all analyses. In contrast, increases in conventional AHI, ODI and arousal index were not associated with deteriorated PVT performance.These results show that our novel parameters describing the severity of intermittent hypoxaemia are significantly associated with increased risk of impaired PVT performance, whereas conventional OSA severity and sleep fragmentation metrics are not. These results underline the importance of developing the assessment of OSA severity beyond the AHI.Parameters considering characteristic properties of desaturations have a significant association with impaired vigilance, highlighting the importance of developing methods beyond the AHI for a more detailed assessment of OSA severity http://bit.ly/2veqxD9