ty -jour t1-人类 ex ex Vivo 肺部灌注JF期间的潜在治疗靶点JF-欧洲呼吸杂志Au -Wong，Aaron au -Zamel，Ricardo au -Yeung，Jonathan au -Bader，Gary D. Au -Dos Santos，Claudia C. Au -Bai -Bai -Bai，Xiaohui au -Wang，Yubo au -yubo au -keshavjee -keshavjee，shaf au -li -li -li -li -liu -liu -liu -liu -liu -liu -liu -liu -liu -liu -liu -liu -liu -li au -li au -li au -au -liu -au -li au -au -liu -au -liu -li-Y1-2020/04/01 UR- http：//www.qdcxjkg.com/content/55/4/19022222.Abstract N2-简介已经开发了Ex Vivo Lung灌注（EVLP）技术，以评估边际捐助者的功能肺部并大大增加了供体肺利用。通过抗生素或纤维蛋白分解剂等损伤特异性治疗，EVLP还被探索为供体肺修复的平台。我们假设，移植和EVLP之间共享的积极表达的途径可能揭示了移植前的肺修复的常见机制和潜在的治疗靶标。材料和方法回顾性转录组学分析是通过“脑死亡后捐赠”的外围组织活检进行的回顾性转录组学分析。46个前/移植后对和49次前/EVLP对。使用途径分析来识别和比较供体肺对移植和EVLP的反应。22途径主要富含移植，包括淋巴细胞激活和细胞死亡以及代谢下调的上调。八个途径主要富含EVLP，包括白细胞功能的下调和血管过程的上调。27个途径通常富集，包括先天炎症，细胞死亡，热应激以及代谢和蛋白质合成的下调。 Of the inflammatory clusters, Toll-like receptor/innate immune signal transduction adaptor signalling had the greatest number of nodes and was central to inflammation. These mechanisms have been previously speculated as major mechanisms of acute lung injury in animal models.Conclusion EVLP and transplantation share common molecular features of injury including innate inflammation and cell death. Blocking these pathways during EVLP may allow for lung repair prior to transplantation.Inflammation and cell death pathways are common molecular features of ischaemia–reperfusion and ischaemia–ex vivo lung perfusion. These may represent therapeutic targets for lung repair prior to transplantation. http://bit.ly/2sIrxOP ER -