@article {Wong1902222作者={黄、亚伦和Zamel里卡多和杨,乔纳森·巴德,加里·d·多斯桑托斯,克劳迪娅c,巴姨,晓惠,Wang Yubo Keshavjee,井和刘,Mingyao}, title ={潜在治疗靶点肺修复在人类体外肺灌注},体积= {55}= {4},elocation-id = {1902222} = {2020}, doi ={10.1183/13993003.02222 -2019},出版商={欧洲呼吸学会},文摘={介绍体外肺灌注(EVLP)技术开发了评估边际供体肺的功能,并显著增加供体肺利用率。188bet官网地址EVLP也一直在探索作为供体肺平台通过injury-specific治疗如抗生素或对修复。我们假设,积极表达途径移植之间共享和EVLP可能揭示常见的肺损伤机制和潜在的治疗靶点修复之前移植。材料和方法回顾性转录组分析的外围组织切片{\ textquotedblleft}脑死后捐赠{\ textquotedblright}肺、46 pre - /移植后对49预处理/ post-EVLP对。路径分析是用来确定和比较的反应供体肺移植和EVLP。结果22通路主要富集在移植,包括upregulation淋巴细胞活化和细胞死亡的差别,对这些基因的新陈代谢。八通道主要富集在EVLP,白细胞功能和upregulation差别包括对这些血管的过程。27途径通常是丰富,包括先天的激活炎症、细胞死亡,热应力的差别,对这些基因的代谢和蛋白质合成。炎症的集群,toll样受体/先天免疫信号转导适配器信号有最大数量的节点和中心炎症。这些机制已经被先前猜测为急性肺损伤动物模型的主要机制。Conclusion EVLP and transplantation share common molecular features of injury including innate inflammation and cell death. Blocking these pathways during EVLP may allow for lung repair prior to transplantation.Inflammation and cell death pathways are common molecular features of ischaemia{\textendash}reperfusion and ischaemia{\textendash}ex vivo lung perfusion. These may represent therapeutic targets for lung repair prior to transplantation. http://bit.ly/2sIrxOP}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/4/1902222}, eprint = {//www.qdcxjkg.com/content/55/4/1902222.full.pdf}, journal = {European Respiratory Journal} }