TY - JOUR T1 -湖北省(中心)和非湖北省(非中心)收治的COVID-19住院患者的临床特点和转归:全国分析中国摩根富林明——欧洲呼吸杂志乔-和J欧元做10.1183/13993003.00562 -2020 SP - 2000562 AU -梁,文非盟-关,Wei-jie AU - Li Cai-chen AU - Li Yi-min盟——梁、Heng-rui盟——赵,易盟——刘Xiao-qing盟——唱,凌AU - Chen Ru-chong AU - Tang春丽AU -王,道盟——王,Qi-hua盟魏盟——他——Chen Zi-sheng AU - Wong Sook-San盟——Zanin马克盟——刘,君非盟-徐,鑫盟——黄,小君非盟- Li Jian-fu盟——或者,李敏AU - Cheng博盟——熊,掸族盟——谢Zhan-hong AU - Ni Zheng-yi盟——胡余盟——刘,Lei盟——山,香港非盟- Lei, Chun-liang盟——彭Yi-xiang盟——魏、李盟——刘,永盟——胡Ya-hua AU -彭,彭AU - Wang Jian-ming盟——刘Ji-yang盟——陈,中盟-李,帮派盟——郑Zhi-jian盟——秋,Shao-qin AU -罗,杰盟——你们,长江三峡盟——朱Shao-yong AU - Cheng Lin-ling盟——你们冯AU - Li Shi-yue AU -郑,《金瓶梅盟——张Nuo-fu盟——钟,南山盟——他,建设Y1 - 20/01/01 UR - //www.qdcxjkg.com/content/early/2020/04/01/13993003.00562-2020.abstract N2 -背景在2019冠状病毒病爆发期间，已经观察到，与中国其他地区相比，湖北省治疗的患者在疾病严重程度和死亡率方面存在一致和相当大的差异。我们试图比较在湖北省内和省外治疗的患者的临床特点和结果，并探讨这些差异背后的因素。方法与国家卫健委合作，建立回顾性队列研究中国住院COVID-19病例。比较境内外患者的临床特征、重症事件发生率、死亡率、重症时间(有创通气、重症监护病房入院或死亡)。此外，还确定了武汉相关暴露(武汉是湖北省的中心和行政中心，推测是导致湖北疫情严重的关键因素)以及症状出现到入院的时间对预后的影响。结果截止数据(2020年1月31日)，共收集31个省级行政区575家医院1590例病例(核心队列)。重症病例和死亡率分别为16.0%和3.2%。 Patients in Hubei (predominantly with Wuhan-related exposure, 597/647, 92.3%) were older (mean: 49.7 versus 44.9 years), had more cases with comorbidity (32.9% versus 19.7%), higher symptomatic burden, abnormal radiologic manifestations, and, especially, a longer waiting time between symptom onset and admission (5.7 versus 4.5 days) compared with patients outside Hubei. Patients in Hubei [severe event rate 23.0% versus 11.1%, death rate 7.3% versus 0.3%, hazards ratio (HR) for critical illness 1.59, 95%CI 1.05–2.41] have a poorer prognosis compared with patients outside of Hubei after adjusting for age and comorbidity. However, among patients outside of Hubei, the duration from symptom onset to hospitalisation (mean: 4.4 versus 4.7 days) and prognosis (HR 0.84, 95%CI 0.40–1.80) were similar between patients with or without Wuhan-related exposure. In the overall population, the waiting time, but neither treated in Hubei nor Wuhan-related exposure, remained an independent prognostic factor (HR 1.05, 1.01–1.08).Conclusion There were more severe cases and poorer outcomes for COVID-19 patients treated in Hubei, which might be attributed to the prolonged duration of symptom onset to hospitalisation in the epicenter. Future studies to determine the reason for delaying hospitalisation are warranted.This study highlights the necessity of urgent and vigorous support of healthcare resources and increased public awareness during the early stages of an outbreak of COVID-19 or similar diseases. ER -