AU - Kikuchi, Hanako AU - Goda, Ayumi AU - Takeuchi, Kaori AU - Inami, Takumi AU - Kohno, Takashi AU - Sakata, Konomi AU - Soejima, Kyoko AU - Satoh，Toru TI -运动不耐受在慢性血栓栓塞肺动脉高压肺血管成形术后援助- 10.1183/13993003.01982 -2019 DP - 2020年1月01 TA -欧洲呼吸杂志PG - 1901982 4100 - 4099 - //www.qdcxjkg.com/content/early/2020/04/01/13993003.01982 2019. -短运动性肺动脉高压常见于慢性血栓栓塞性肺动脉高压患者，这些患者在运动时呼吸急促，尽管静息时肺动脉压力正常，但运动能力降低;然而，运动性肺动脉高压与运动能力之间的关系尚不清楚。本研究的目的是确定在肺球囊血管成形术(BPA)后静息血流动力学正常的慢性血栓栓塞性肺动脉高压患者中，运动性肺动脉高压是否与运动能力和呼吸效率有关。双酚a治疗慢性血栓栓塞性肺动脉高压249例(年龄63±14岁;静息时平均肺动脉压(< 25mmhg)和楔压(≤15mmhg)正常的男性/女性，用右心导管进行心肺运动试验。运动时肺动脉平均压力-心输出量(mPAP-CO)在多个点上绘制。运动性肺动脉高压的定义为mPAP-CO斜率大于3。结果运动性肺动脉高压组(n=116)静息时肺血管阻力明显高于非运动性肺动脉高压组(n=133)。前一组的耗氧量峰值较低(13.5±3.8 vs 16.6±4.7 mL·min−1·kg−1,p;0.001)。 The mPAP-CO slope was negatively correlated with the peak oxygen consumption (r=−0.45, p<0.001) and positively correlated with the minute ventilation versus carbon dioxide output slope (r=0.39, p<0.001).Conclusions Impaired exercise capacity and ventilatory efficiency were observed in patients with chronic thromboembolic pulmonary hypertension who had normalised pulmonary artery pressure at rest but exercise pulmonary hypertension.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Kikuchi has nothing to disclose.Conflict of interest: Dr. Goda has nothing to disclose.Conflict of interest: Dr. Takeuchi has nothing to disclose.Conflict of interest: Dr. Inami has nothing to disclose.Conflict of interest: Dr. Kohno has nothing to disclose.Conflict of interest: Dr. Sakata has nothing to disclose.Conflict of interest: Dr. Soejima has nothing to disclose.Conflict of interest: Dr. Satoh has nothing to disclose.