% 0期刊文章%菊池,花子% Goda,亚由美%竹内,薰% Inami, Takumi % Kohno,隆%坂田,Konomi % Soejima,恭子%的佐藤晴Toru % T运动不耐受在慢性血栓栓塞肺动脉高压肺血管成形术后2020% % D J R 10.1183/13993003.01982 -2019%欧洲呼吸杂志% P 1901982 % X背景运动肺动脉高压是常见的慢性血栓栓塞肺动脉高压患者期间呼吸短促的经历锻炼和运动能力下降,尽管正常肺动脉压力在休息;然而,锻炼肺动脉高压和运动能力之间的关系尚不清楚。我们旨在确定运动肺动脉高压与运动能力和通气效率在慢性血栓栓塞肺动脉高压患者正常休息后血液动力学的肺气囊血管成形术(BPA)。患者和方法二百四十九慢性血栓栓塞肺动脉高压患者接受BPA(年龄、63±14年;正常的男人/女人,62/187)平均肺动脉压(< 25 mmHg)和楔压(≤15毫米汞柱)静止接受心肺运动试验对心脏导管。平均肺动脉pressure-cardiac输出(mPAP-CO)在运动是绘制在多个点。锻炼肺动脉高压是由mPAP-CO斜率大于3的定义。结果在休息,肺血管阻力明显高于运动肺动脉高压组(n = 116)比非运动性肺动脉高压组(n = 133)。更低的峰值耗氧量(13.5±3.8和16.6±4.7毫升·敏−1·公斤−1,p < 0.001),观察前组。mPAP-CO斜率与峰值耗氧量是负相关(r =−0.45, p < 0.001),与每分通气量呈正相关与二氧化碳输出斜率(r = 0.39, p < 0.001)。结论运动能力受损和通气效率观察在慢性血栓栓塞肺动脉高压患者正常肺动脉压力静止但锻炼肺动脉高压。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Kikuchi has nothing to disclose.Conflict of interest: Dr. Goda has nothing to disclose.Conflict of interest: Dr. Takeuchi has nothing to disclose.Conflict of interest: Dr. Inami has nothing to disclose.Conflict of interest: Dr. Kohno has nothing to disclose.Conflict of interest: Dr. Sakata has nothing to disclose.Conflict of interest: Dr. Soejima has nothing to disclose.Conflict of interest: Dr. Satoh has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2020/04/01/13993003.01982-2019.full.pdf