TY - JOUR T1 - 利用囊性纤维化结构肺部疾病的早期标志物，以改善结果JF - 欧洲呼吸杂志JO - 欧洲呼吸j执行 - 10.1183 / 13993003.00105-2020 VL - 55 - 4 SP - 2000105 AU - 水槽，帕特里克A.AU - VanDevanter，唐纳德R. Y1 - 2020年4月1日UR - //www.qdcxjkg.com/content/55/4/2000105.abstract N2 - 囊性纤维化（CF）肺部疾病的自然史已described as a complex process of obstruction, infection, and inflammation, all contributing to airways injury and eventual structural disease (i.e. bronchiectasis). Consequences of the CF genetic abnormality begin in utero and are the basis for newborn screening for elevated levels of circulating immunoreactive trypsinogen (IRT) [1]. Thus, it should be no surprise that the process of airway obstruction begins immediately at birth. Ample cross-sectional evidence has been published of airway obstruction, inflammation, bacterial infection, bronchial wall thickening, air trapping and bronchiectasis in the first year of life for infants with CF [2].Wijker and colleagues have demonstrated the link of inflammation and obstruction to eventual structural disease in CF. Now we may have another clinical endpoint by which we can judge the impact of early interventions. http://bit.ly/2v5A5Qw ER -