TY - JOUR T1 -囊性纤维化结构肺疾病的早期标志物:后续ACFBAL队列的JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01694 -2019欧元六世- 55 - 4 SP - 1901694 AU Wijker纳奥米•e . AU -维德马苏珊娜AU - Grimwood,基思盟——狡猾,彼得·d . AU -伯恩斯,凯瑟琳a . AU -卡林,John b . AU -库珀,Peter J . AU -罗伯逊,科林·f . AU -宏伟,r .约翰盟,凯默van de Corput Mariette pc AU -切尼,乔伊斯盟——Tiddens伤害A.W.M. AU -温赖特,克莱尔·e . A2 -摘要N2 -对于晚期囊性纤维化(CF)结构性肺疾病的早期预测因子了解甚少。本研究检测了在5岁时完成澳大亚CF支气管肺泡灌洗(ACFBAL)临床试验并参与观察性随访研究(CF- fab)的儿童进行性结构肺异常的早期预测因子。8个澳大利亚和新西兰的CF中心参与了CF- fab，并为完成ACFBAL研究并在5岁时进行基线扫描的儿童提供后续胸部计算机断层扫描(CT)。CT扫描采用PRAGMA-CF评分注记。顺序回归分析和线性回归用于调查随访时的PRAGMA-CF (Perth-Rotterdam注释网格形态分析)结果和ACFBAL研究期间测量的变量之间的相关性。157名ACFBAL儿童中有99名(平均±sd 13±1.5岁)参与了CF-FAB研究。随访时支气管扩张的概率随气道疾病严重程度的增加而增加。在多元回归分析中(保留p<的因素;0.05)，随访时支气管扩张的程度与基线肺不张相关(或7.2,95% CI 2.4-22;支气管肺泡灌洗(BAL) log2白细胞介素(IL)-8 (OR 1.2, 95% CI 1.05-1.5;p=0.010)和体重指数z-score (OR 0.49, 95% CI 0.24-1.00; p=0.05) at age 5 years. Percentage trapped air at follow-up was associated with BAL log2 IL-8 (coefficient 1.3, 95% CI 0.57–2.1; p<0.001) at age 5 years.The extent of airway disease, atelectasis, airway inflammation and poor nutritional status in early childhood are risk factors for progressive structural lung disease in adolescence.In children with cystic fibrosis, airways disease severity on chest computed tomography at age 5 years increased the risk of bronchiectasis in adolescence and its extent was predicted by poorer nutrition, airway inflammation, and atelectasis http://bit.ly/2Nnk8LW ER -