@article {Wijker1901694，作者= {Wijker，直美E.和Vidmar的，苏珊娜和葛林伍德，Keith和狡猾，彼得D.和三郎，凯瑟琳A.和卡林，约翰·B和Cooper，彼得J.和Robertson，科林˚F. and Massie, R. John and Kemner van de Corput, Mariette P.C. and Cheney, Joyce and Tiddens, Harm A.W.M. and Wainwright, Claire E.}, editor = {, and , and Wainwright, Claire E. and Grimwood, Keith and Cheney, Joyce and George, Narelle and Carlin, John B. and Robertson, Colin F. and Vidmar, Suzanna and Carzino, Rosemary and Moodie, Marj and Armstrong, David S. and Cooper, Peter J. and Martin, A. (James) and Whitehead, Bruce and Byrnes, Catherine A. and Tiddens, Harm A.W.M. and , and Wainwright, Claire E. and Grimwood, Keith and Sly, Peter D. and Tiddens, Harm A.W.M. and Rogers, Geraint and Massie, Richard (John) and Robertson, Colin F. and Cooper, Peter J. and Byrnes, Catherine A. and Vidmar, Suzanna and Martin, A.(James) and Whitehead, Bruce and Armstrong, David and Carlin, John B. and Wark, Peter and , and Gailer, Nicholas and Smith, Natalie and Moss, Careana and Jess, Katrina and Yarrow, Peta and McArthur, Merilyn and Forbes, Sam and Selvadurai, Hiran and Ranganathan, Sarath and Robinson, Phil and Zajakovski, Natalie and Erasmus, MC and Wiel, Els Van Der}, title = {Early markers of cystic fibrosis structural lung disease: follow-up of the ACFBAL cohort}, volume = {55}, number = {4}, elocation-id = {1901694}, year = {2020}, doi = {10.1183/13993003.01694-2019}, publisher = {European Respiratory Society}, abstract = {Little is known about early predictors of later cystic fibrosis (CF) structural lung disease. This study examined early predictors of progressive structural lung abnormalities in children who completed the Australasian CF Bronchoalveolar Lavage (ACFBAL) clinical trial at age 5-years and participated in an observational follow-up study (CF-FAB).Eight Australian and New Zealand CF centres participated in CF-FAB and provided follow-up chest computed-tomography (CT) scans for children who had completed the ACFBAL study with baseline scans at age 5-years. CT scans were annotated using PRAGMA-CF scoring. Ordinal regression analysis and linear regression were used to investigate associations between PRAGMA-CF (Perth{\textendash}Rotterdam Annotated Grid Morphometric Analysis for CF) outcomes at follow-up and variables measured during the ACFBAL study.99 out of 157 ACFBAL children (mean{\textpm}sd age 13{\textpm}1.5 years) participated in the CF-FAB study. The probability of bronchiectasis at follow-up increased with airway disease severity on the baseline CT scan. In multiple regression (retaining factors at p\<0.05) the extent of bronchiectasis at follow-up was associated with baseline atelectasis (OR 7.2, 95\% CI 2.4{\textendash}22; p<= 0.001), bronchoalveolar lavage (BAL) log2 interleukin (IL)-8 (OR 1.2, 95\% CI 1.05{\textendash}1.5; p=0.010) and body mass index z-score (OR 0.49, 95\% CI 0.24{\textendash}1.00; p=0.05) at age 5 years. Percentage trapped air at follow-up was associated with BAL log2 IL-8 (coefficient 1.3, 95\% CI 0.57{\textendash}2.1; p\<0.001) at age 5 years.The extent of airway disease, atelectasis, airway inflammation and poor nutritional status in early childhood are risk factors for progressive structural lung disease in adolescence.In children with cystic fibrosis, airways disease severity on chest computed tomography at age 5 years increased the risk of bronchiectasis in adolescence and its extent was predicted by poorer nutrition, airway inflammation, and atelectasis http://bit.ly/2Nnk8LW}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/4/1901694}, eprint = {//www.qdcxjkg.com/content/55/4/1901694.full.pdf}, journal = {European Respiratory Journal} }