Ty-Jour T1 - 血单核细胞作为特发性肺纤维化的潜在预后标志物：澳大利亚IPF注册管理机构的分析JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003.01855-2019 VL - 55 IS - 4 SP - 1901855AU - Teoh, Alan K.Y. AU - Jo, Helen E. AU - Chambers, Daniel C. AU - Symons, Karen AU - Walters, Eugene H. AU - Goh, Nicole S. AU - Glaspole, Ian AU - Cooper, Wendy AU - Reynolds, Paul AU - Moodley, Yuben AU - Corte, Tamera J. Y1 - 2020/04/01 UR - //www.qdcxjkg.com/content/55/4/1901855.abstract N2 - Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing lung disease that leads to unrelenting dyspnoea and chronic cough, and ultimately respiratory failure [1]. IPF is characterised by a variable disease course that remains difficult to predict for an individual at diagnosis [2]. In the current era, with the advent of anti-fibrotic therapy which can slow disease progression, it is increasingly important to identify patients with early disease and to target those patients who are at most risk of rapid decline [3]. However, despite multiple studies proposing novel potential prognostic biomarkers, the current American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Society guideline statements dismissed the use of these biomarkers except in a research capacity [3, 4].Blood monocytes have been recently proposed as a potential prognostic marker for IPF. Data from the Australian IPF registry have shown that elevated monocytes, neutrophils and total leukocytes significantly predict poorer survival in IPF patients. http://bit.ly/38GP7f0 ER -