TY - T1的规范数据为多个呼吸washout outcomes in school-aged Caucasian children JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01302-2019 VL - 55 IS - 4 SP - 1901302 AU - Anagnostopoulou, Pinelopi AU - Latzin, Philipp AU - Jensen, Renee AU - Stahl, Mirjam AU - Harper, Alana AU - Yammine, Sophie AU - Usemann, Jakob AU - Foong, Rachel E. AU - Spycher, Ben AU - Hall, Graham L. AU - Singer, Florian AU - Stanojevic, Sanja AU - Mall, Marcus A. AU - Ratjen, Felix AU - Ramsey, Kathryn A. Y1 - 2020/04/01 UR - //www.qdcxjkg.com/content/55/4/1901302.abstract N2 - Background The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. The aim of this study was to generate reference values for N2MBW outcomes in a cohort of healthy Caucasian school-aged children.Methods N2MBW data from healthy Caucasian school-age children between 6 and 18 years old were collected from four experienced centres. Measurements were performed using an ultrasonic flowmeter (Exhalyzer D, Eco Medics AG, Duernten, Switzerland) and were analysed with commercial software (Spiroware version 3.2.1, Eco Medics AG). Normative values and upper limits of normal (ULN) were generated for lung clearance index (LCI) at 2.5% (LCI2.5%) and at 5% (LCI5%) of the initial nitrogen concentration and for moment ratios (M1/M0 and M2/M0). A prediction equation was generated for functional residual capacity (FRC).Results Analysis used 485 trials from 180 healthy Caucasian children aged from 6 to 18 years old. While LCI increased with age, this increase was negligible (0.04 units·year–1 for LCI2.5%) and therefore fixed ULN were defined for this age group. These limits were 7.91 for LCI2.5%, 5.73 for LCI5%, 1.75 for M1/M0 and 6.15 for M2/M0, respectively. Height and weight were found to be independent predictors of FRC.Conclusion We report reference values for N2MBW outcomes measured on a commercially available ultrasonic flowmeter device (Exhalyzer D, Eco Medics AG) in healthy school-aged children to allow accurate interpretation of ventilation distribution outcomes and FRC in children with lung disease.This study provides reference values for nitrogen multiple breath washout outcomes in healthy Caucasian children from 6 to 18 years old, measured with a commercially available device http://bit.ly/2rsab8v ER -