TY - JOUR T1 -实验性呼吸困难干扰运动和认知:一个随机试验JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00054 -2020欧元SP - 2000054 AU Lawi大卫盟——Dupuis Elise-Lozeron AU -贝瑞,格里高利盟——Allali Gilles盟——Similowski托马斯AU -阿德勒,丹Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/03/26/13993003.00054 - 2020. -抽象N2 -背景慢性呼吸道疾病与认知功能障碍,但是，是否呼吸困难本身对认知的负面影响还没有得到证实。经历呼吸困难的受试者的大脑皮层网络在其他需要认知输入的任务中也会被激活，并可能通过相互干扰而引发负面影响。方法:对40名健康成人进行交叉随机试验，研究实验性呼吸困难是否会对运动和认知功能产生负面影响。交叉条件是卸载呼吸或加载呼吸使用吸气阈值负荷。为了评估参与者的运动能力，我们对他们进行了Timed Up and Go测试。采用类别语用流利度测试、音位语用流利度测试、执行功能测试、处理速度测试、直接和间接数字广度测试来评估认知功能。无负载呼吸与负载呼吸执行定时Up和Go测试的平均时差为−0.752 s(−1.012 ~−0.492;术中,0.001)。无负荷呼吸时，受试者的执行功能、加工速度和工作记忆表现较好。结论我们的数据表明呼吸阈值负荷诱发呼吸困难对健康成人的运动和认知功能有重大影响。脚注:这份手稿最近已被《欧洲呼吸杂志》接受发表。在我们的制作团队进行编辑和排版之前，它以可接受的形式在这里出版。 After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lawi has nothing to disclose.Conflict of interest: Dr. Dupuis-Lozeron has nothing to disclose.Conflict of interest: Dr. Berra has nothing to disclose.Conflict of interest: Dr. Allali has nothing to disclose.Conflict of interest: Dr. SIMILOWSKI reports personal fees from AstraZeneca France, personal fees from Boerhinger Ingelheim France, personal fees from GSK France, personal fees and non-financial support from Novartis France, personal fees from TEVA France, personal fees from Chiesi France, personal fees from Lungpacer Inc, personal fees from ADEP Assistance, grants from Air Liquide Medical Systems, outside the submitted work.Conflict of interest: Dr. Adler reports grants from The Geneva Pulmonary League, during the conduct of the study. ER -