RT期刊文章SR电子T1呼出一氧化氮轨迹模式和决定因素的学生在7年时间内摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 2000011 10.1183/13993003.00011 -2020 A1加西亚,埃里卡A1,曰A1 Rappaport,爱德华·b·A1博Kiros A1某个,帕特里克·A1 Silkoff Philip e . A1 Molshatzki诺亚188bet官网地址A1 Gilliland,弗兰克·d·A1埃克尔Sandrah p .年2020 UL //www.qdcxjkg.com/content/early/2020/03/26/13993003.00011 - 2020. -抽象AB分数呼出一氧化氮(FENO50)、过敏性气道炎症的标志物,用于呼吸系统研究和哮喘临床护理;然而,它的轨迹,随着年龄增长在儿童时期没有特点。我们检查了FENO50纵向体细胞增长时期的重要描述轨迹在童年和青春期健康的参与者和评价临床因素轨迹的潜在决定因素。六点FENO50收集访问超过1791 8年以人群为基础的队列的学生没有哮喘(中位年龄在条目8.4)。光滑的性别FENO50轨迹估计使用普遍添加剂混合模型,与participant-level随机效应。我们评估是否受到种族、性别轨迹BMI百分位,过敏性鼻炎或青春期。不同FENO50模式性观察到在以后的童年和几个因素与FENO50水平或改变有关FENO50参与者年龄。FENO50-age轨迹被性别直到年龄11.5∼相似,之后,男性比女性更FENO50变化。这种分歧在FENO50-age轨迹正值青春期。较高的男性BMI百分位开始减毒FENO50-age斜坡。在男性中,在非拉美裔白人FENO50水平低。 Among both sexes, participants with rhinitis had higher FENO50. FENO50 levels within individuals tracked over time; however, there was considerable variation in FENO50 patterns across participants.FENO50 trajectories from longitudinal data provide evidence of sex differences coinciding with puberty, suggesting potential hormone link. Improved understanding of determinants of FENO50 trajectories is needed to realise the potential for using individualised predicted FENO50 trajectories.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Garcia has nothing to disclose.Conflict of interest: Dr. zhang reports grants from NIH, grants from AHRQ, grants from VA, grants from CDC, outside the submitted work.Conflict of interest: Dr. Rappaport has nothing to disclose.Conflict of interest: Dr. Berhane reports grants from NIH, during the conduct of the study.Conflict of interest: Dr. Muchmore reports grants from National Institute of Environmental Health Sciences, USA, during the conduct of the study; In addition, Dr. Muchmore has a patent PCT/US2018/042316 pending.Conflict of interest: Dr. Silkoff has nothing to disclose.Conflict of interest: Dr. Molshatzki has nothing to disclose.Conflict of interest: Dr. Gilliland has nothing to disclose.Conflict of interest: Dr. Eckel reports grants from NIH, during the conduct of the study.