% 0期刊文章% Ulrike格林%我们h . Wijga %杰拉德h . Koppelman % Judith m . Vonk % h A . Smit %伯特Brunekreef % T空气污染和哮喘的发展从出生到成年早期% D J 2020% R 10.1183/13993003.00147 -2020%欧洲呼吸杂志% P 2000147 % X背景空气污染与儿童和成人哮喘的发展有关,但对哮喘的影响发展从青春期过渡到成年时还不清楚。成人研究缺乏历史曝光,因此无法评估风险的相关性在不同时期的生活。我们评估早期生活的相关性,最近空气污染暴露哮喘发展从出生到成年早期。方法我们使用数据的3687名参与者的潜在荷兰PIAMA出生队列和有关哮喘发病率在20岁之前估计的二氧化氮(NO2)浓度,PM2.5吸光度(“煤烟”)和颗粒物直径< 2.5μm (PM2.5), < 10μm (PM10)和2.5 -10μm (PMcoarse)住宅地址。我们评估总体、不同年龄组对空气污染暴露与离散时间风险模型,调整了潜在的混杂因素。结果总的来说,我们发现患哮喘的发病率更高,直到20岁高暴露在所有污染物出生地址(调整后的优势比(95%置信区间)从1.09 (1.01 - -1.18)PM10对NO2) 1.20(1.10 - -1.32) /四分位范围增加),随着年龄的增长,而持久。类似的协会观察最近接触定义为暴露在当前的家庭住址。与点two-pollutant模型,对NO2持久化。结论暴露于空气污染,特别是从机动交通,在生命早期哮喘的发展可能有长期的后果是增加患哮喘的几率在童年和青春期到成年早期。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。 After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Gehring has nothing to disclose.Conflict of interest: Dr. Wijga has nothing to disclose.Conflict of interest: Dr. Koppelman reports grants from Lung Foundation of the Netherlands, during the conduct of the study; grants from Lung Foundation of the Netherlands, TETRI Foundation, UBBO EMMIUS Foundation, TEVA the Netherlands, VERTEX, GSK, other from GSK, outside the submitted work.Conflict of interest: Dr. Vonk has nothing to disclose.Conflict of interest: Dr. Smit has nothing to disclose.Conflict of interest: Dr. Brunekreef has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2020/03/26/13993003.00147-2020.full.pdf