PT -期刊文章盟Gaisl托马斯盟——Rejmer Protazy AU -泰尔,Sira AU -海丽,莎拉·r . AU - Osswald进行,马丁AU -鲁斯,马格达雷娜盟——布洛赫,康拉德•e . AU,斯特拉德林John r . AU -科勒,马尔科姆TI - CPAP治疗的依从性不佳对阻塞性睡眠呼吸暂停的症状:一项随机,双盲,对照试验援助- 10.1183/13993003.01526 -2019 DP - 2020年3月01 TA -欧洲呼吸杂志》第六PG - 1901526 - 55 IP - 3 4099 - //www.qdcxjkg.com/content/55/3/1901526.short 4100 - //www.qdcxjkg.com/content/55/3/1901526.full所以欧元和J2020 3月01;55 AB -介绍持续气道正压(CPAP)目前是嗜睡患者的首选治疗阻塞性睡眠呼吸暂停(OSA);然而,坚持经常被认为是次优的。我们调查的影响,次优CPAP的使用目的和阻塞性睡眠呼吸暂停患者主观睡眠参数。材料和方法在这2周,平行,双盲、随机对照试验我们注册是严重阻塞性睡眠呼吸暂停综合症患者过度预处理白天嗜睡(埃普沃思嗜睡量表(ESS)的分数在10分)曾CPAP依从性不佳在≥12个月(平均每晚使用时间3 - 4小时)。患者通过最小化分配开始CPAP(“伪装”CPAP)或继续CPAP (“CPAP治疗”)。与历史先验贝叶斯分析计算后验概率的优势。结果在2016年5月,2018年11月,57例(60±8岁,79%为男性,93%是白人)在总分配,和52完成这项研究在每个臂(50%)包括在最终的分析中。未经调整的ESS评分增加2.4点(95% CI 0.6 - -4.2, p = 0.01) sham-CPAP组相比,继续CPAP治疗。的概率优势的CPAP治疗假ESS CPAP是90.4%,90.1%为收缩压和舒张压为80.3%。Conclusions Patients with moderate-to-severe OSA and daytime sleepiness are still getting a substantial benefit from suboptimal CPAP adherence, albeit not as much as they might get if they adhered more. Whether a similar statement can be made for even lower adherence levels remains to be established in future trials.Patients with obstructive sleep apnoea and daytime sleepiness are still getting a substantial benefit from suboptimal CPAP adherence (i.e. 3–4 h per night), albeit not as much as they might get if they adhered more http://bit.ly/2Phgeo2