作者@article {Abidi1901467 ={阿,Syed和干,杰伊和Assao Neino, Mourtala穆罕默德和爆炸,迪迪和趣事,安德里亚和Brode,萨拉和坎贝尔,乔纳森·r·卡萨斯,以斯帖c和Conradie,弗朗西斯卡Dravniece, Gunta杜横,菲利普和Falzon,丹尼斯和Jaramillo,埃内斯托和Kuaban,克里斯托弗和局域网,一度和兰格,Christoph和李裴智和Makhmudova Mavluda Maug,昂山素季(Aung Kya洁和孟迪克和Migliori Giovanni Battista和米勒,安和Myrzaliev, Bakyt Ndjeka,诺伯特和Noeske J {\ " u} rgen Parpieva, Nargiza Piubello,阿尔贝托,Schwoebel Val {\ ' e} rie Sikhondze, Welile Singla,鲁派克Souleymane,迪亚拉Bassirou和Tr {\ ' e} bucq, Arnaud和Van Deun,阿尔芒和维尼,凯丽和韦卡琳和张,贝蒂精选和艾哈迈德汗Faiz}, title ={标准化短方案和个性化长方案对利福平或耐多药结核病},体积= {55}= {3},elocation-id = {1901467} = {2020},我们试图比较世界卫生组织(WHO)推荐的两种治疗利福平或耐多药(RR/MDR)结核病(TB)的方案的188bet官网地址有效性:标准化方案为9个月12个月(短方案)和个体化方案为>=20个月(长方案)。我们收集了个体患者的数据，这些数据是通过系统性回顾和公众对数据的需求确定的观察性研究。我们纳入了符合世卫组织短期方案资格标准的患者:以前未使用二线药物，以及氟喹诺酮和二线注射药敏感的RR/MDR-TB。我们使用倾向评分匹配、混合效应元回归计算失败或复发、开始治疗12个月内死亡和失随访的调整优势比和调整风险差异(aRDs)。我们纳入了9项短期饮食方案研究中的3378人中的2625人(77.7% \%)和53项长期饮食方案研究中的13104人中的2717人(20.7% \%)。短疗程组的治疗成功率高于长疗程组(合并比例分别为80.0\%和75.3%)，因为前者的随访损失较小(aRD -0.15, 95\% CI -0.17{\textendash} -0.12)。失败或复发的风险差异略高与短方案整体CI (aRD 0.02, 95 \ % 0 {\ textendash} 0.05)和更大的大小与基线抗吡嗪酰胺(aRD 0.12, 95 \ % CI 0.07 {\ textendash} 0.16), prothionamide /乙硫异烟胺(aRD 0.07, 95 \ % CI -0.01 {\ textendash} 0.16)、乙胺丁醇(aRD 0.09,95 \ % CI 0.04 {\ textendash} 0.13)。In patients meeting WHO criteria for its use, the standardised shorter regimen was associated with substantially less loss to follow-up during treatment compared with individualised longer regimens and with more failure or relapse in the presence of resistance to component medications. Our findings support the need to improve access to reliable drug susceptibility testing.Standardised shorter regimens for RR/MDR-TB had substantially lower risk of loss to follow-up than individualised longer regimens, but also higher risk of failure or relapse if there was resistance to component drugs http://bit.ly/2RQgXzq}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/3/1901467}, eprint = {//www.qdcxjkg.com/content/55/3/1901467.full.pdf}, journal = {European Respiratory Journal} }