TY - T1的肺内的气道平滑肌hyperreactive截然不同的蛋白质组的哮喘JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02178 -2019欧元SP - 1902178 AU Ijpma吉斯。非盟- Kachmar琳达盟——Panariti爱丽丝盟——Matusovsky奥列格•s . AU - Torgerson达拉AU -贝内代蒂,安德里亚盟——Lauzon anne - marie Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/03/12/13993003.02178 - 2019. -抽象N2 -收缩的航空公司在哮喘恶化的气管平滑肌收缩(ASM)。尽管人们普遍认为ASM hypercontractile哮喘,这尚未得到明确的证明。是增加的结果ASM气道高反应质量是否还单独或增加肌肉的收缩力代单位直接决定了治疗的潜在途径。评估是否hypercontractile ASM我们执行一系列的力学测量从肺内的航空公司和孤立的ASM trachealis从人类肺部。我们分析ASM和整个呼吸道蛋白质组验证如果蛋白质组变化导致ASM属性的变化。我们报告孤立ASM收缩应力和刚度的增加特定的人类肺内的支气管哮喘,哮喘气道阻力增加。其他收缩参数没有改变。公正的质谱数据的主成分分析显示明显的集群哮喘受试者对ASM特定的蛋白质。整个呼吸道蛋白质组显示upregulation结构蛋白质。我们没有找到任何证据不同肌凝蛋白的规定活动哮喘ASM。总之,我们表明,ASM确实hyperreactive在哮喘肺内的航空公司的水平。 We identified several proteins that are upregulated in asthma that could contribute to hyperreactivity. Our data also suggest enhanced force transmission associated with enrichment of structural proteins in the whole airway. These findings may lead to novel directions for treatment development in asthma.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. IJpma has nothing to disclose.Conflict of interest: Dr. Kachmar has nothing to disclose.Conflict of interest: Dr. PANARITI has nothing to disclose.Conflict of interest: Dr. Matusovsky has nothing to disclose.Conflict of interest: Dr. Torgerson has nothing to disclose.Conflict of interest: Dr. Benedetti has nothing to disclose.Conflict of interest: Dr. Lauzon has nothing to disclose. ER -