Ty-Jour T1 - 孕妇吸烟期间的后代会发生成人哮喘发病：从出生到46岁时的后续工作JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003 - 1901857 Au - TopPila-Salmi，Sanna Au - Luukkainen，Annika T. Au - Xu，Baizhuang Au - Lampi，Jussi Au - Auvinen，Juha Au - Dhaygude，Kishor Au - Järvelin，Marjo-Riitta Au - Pekkanen，Juha Y1 - 2020 / 01/01- //www.qdcxjkg.com/content/early/2020/03/12/13993003.012/13993003.01857-2019.Abstract n2 - 理由环境烟草烟雾暴露（ETS）增加了儿童的哮喘风险。对成人发病哮喘的产前ETS知识有限。目的，以确定产前ETS和成人发病哮喘之间的关联。测量和主要结果问卷和5200人的临床资料，由31岁以上没有医生诊断的哮喘。北芬兰出生队列1966年使用了研究。通过调整后的多变量回归分析研究了妊娠期妊娠期妊娠期妊娠早期和成人后代肺功能的孕妇吸烟协会。21岁至46岁之间的医生诊断哮喘的累积发病率为5.1％，妇女中有8.8％。妊娠烟雾暴露与成年人发病哮喘相关联（调整的赔率比1.54,95％置信区间1.04-2.29），即在报告过去未诊断的哮喘的后代（大量比例9.63,95％置信区间2.28-40.67）或过去咳嗽（3.21,95％CI 1.71-6.05）。在31岁之间妊娠烟雾暴露和后代FEV1 / FVC比率之间检测到显着的关联。在后代用Haplotype RS11702779-AA的Runx1妊娠烟雾暴露与成人发病哮喘有关（5.53,95％CI 2.11-14.52，调整后的p用于相互作用0.10）。怀孕期间的母亲吸烟与哮喘累积发生率有关在31到46年之间的后代。 The association was accentuated in offspring who reported at age 31 as having past respiratory problemsand/or, who had haplotype rs11702779-AA. Also a reduction in FEV1/FVC ratio was observed at age 31 years in offspring with gestational smoke exposure. These results could reflect early vulnerability of offspring's airways to ETS and its putative long-term effects.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Toppila-Salmi reports other from Mylan Laboratories Ltd, other from ERT Ltd, other from Roche Products Ltd, outside the submitted work.Conflict of interest: Dr. Luukkainen has nothing to disclose.Conflict of interest: Dr. Xu has nothing to disclose.Conflict of interest: Dr. Lampi has nothing to disclose.Conflict of interest: Dr. Auvinen has nothing to disclose.Conflict of interest: Dr. Dhaygude has nothing to disclose.Conflict of interest: Dr. Järvelin has nothing to disclose.Conflict of interest: Dr. Pekkanen has nothing to disclose. ER -