@article {toppila-salmi1901857，作者= {toppila-salmi，sanna and luukkainen，annika t. and xu，baizhuang and baizhuang and Lampi，Jussi和Auvinen，Auvinen，Juha和Juha和Dhaygude，Kishor，Kishor和J {Pekkanen，Juha}，title = {怀孕期间的孕产妇吸烟会影响后代哮喘的成人哮喘发作：从出生到46岁的后续}，Elocation-id = {1901857}，年= {2020}，doi = {10.1183/ doi = {10.1183/ = {10.1183/13993003.01857-2019}，出版商= {欧洲呼吸社会}，188bet官网地址摘要= {{原理环境烟草烟雾暴露（ETS）增加儿童的哮喘风险。成人哮喘的产前ETS的了解有限和成人哮喘。测量和主要结果问卷调查表和5200人的临床数据，没有医生诊断为31岁的医生诊断，北部芬兰出生队列1966年进行了研究。怀孕，物理发作通过调整后的多元回归分析，研究了成人后代中CIAN诊断的哮喘和肺功能。在31至46岁之间诊断哮喘的医师诊断的累积发生率为5.1 \％，在女性中为8.8 \％。妊娠烟雾暴露与后代的成人发作哮喘有关（调整后的比值比1.54，95 \％置信区间1.04 {\ textendandash} 2.29），即在过去的未诊断哮喘的后代中（妇女的哮喘比值9.63，95 \％\％\％）置信区间2.28 {\ textendash} 40.67）或喘息的咳嗽（3.21，95 \％CI 1.71 {\ textendendash} 6.05）。在31岁的妊娠烟雾暴露和后代{\ texquoteright} s FEV1/FVC比之间发现了显着关联。 In offspring with the haplotype rs11702779-AA of RUNX1 gestational smoke exposure was associated with adult onset asthma (5.53, 95\% CI 2.11{\textendash}14.52, adjusted p for interaction 0.10).Conclusions Maternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between 31 and 46 years. The association was accentuated in offspring who reported at age 31 as having past respiratory problemsand/or, who had haplotype rs11702779-AA. Also a reduction in FEV1/FVC ratio was observed at age 31 years in offspring with gestational smoke exposure. These results could reflect early vulnerability of offspring{\textquoteright}s airways to ETS and its putative long-term effects.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Toppila-Salmi reports other from Mylan Laboratories Ltd, other from ERT Ltd, other from Roche Products Ltd, outside the submitted work.Conflict of interest: Dr. Luukkainen has nothing to disclose.Conflict of interest: Dr. Xu has nothing to disclose.Conflict of interest: Dr. Lampi has nothing to disclose.Conflict of interest: Dr. Auvinen has nothing to disclose.Conflict of interest: Dr. Dhaygude has nothing to disclose.Conflict of interest: Dr. J{\"a}rvelin has nothing to disclose.Conflict of interest: Dr. Pekkanen has nothing to disclose.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2020/03/12/13993003.01857-2019}, eprint = {//www.qdcxjkg.com/content/early/2020/03/12/13993003.01857-2019.full.pdf}, journal = {European Respiratory Journal} }