Pt-journal文章Au - Stek，Cari Au-allwood，Brian Au - Du Bruyn，Elsa Au - Buyze，Jozefien Au - Schutz，Charlotte Au - Thienemann，Frientrich Au - Lombard，阿德利·奥尔库纳，罗伯特J.Au - Meintjes，格雷梅奥 - 林肯，吕德·蒂 - 艾滋病毒关联结核病，结核病 - 虹膜和泼尼松效果肺功能艾滋病 - 10.11.01692-2019 DP - 2020 3月TA - 欧洲呼吸期刊PG - 1901692 VI - 55 IP -3 4099 - //www.qdcxjkg.com/content/55/3/1901692.short 4100 - //www.qdcxjkg.com/content/55/3/1901692.full so - 欧元respirj2020 3月01日;55 ab - 残留的肺损伤是治疗结核病（TB）后常见。艾滋病毒相关结核病患者的肺功能数据是稀缺的，特别是在矛盾的TB相关免疫重建炎症综合征（TB-IRIS）和预防泼尼松的背景下。我们的旨在确定艾滋病毒相关TB和CD4计数≤100细胞患者肺功能异常的患病率·μl-1并评估预防性泼尼松和矛盾的TB-IRIS对肺部损伤的影响。我们进行了肺活量测定法，6分钟的步行试验（6MWT）和基线（第0周）和胸部射线照相，在预先试验的参与者的第4,12和28周，评估了28天的泼尼松过程，以防止艾滋病毒患者TB-IRI- 可分配的Tb开始抗逆转录病毒治疗.153参与者在一个或多个时间点进行肺活量测定和/或6MWT。在第28周，第28周，66％的参与者中，66％的参与者中出现异常肺活量测量测量值;低强制生命能力是最常见的异常。胸部射线照片在大多数参与者中表现出很少或没有异常。 Prednisone use resulted in a 42 m greater 6-min walk distance and a 4.9% higher percentage of predicted forced expiratory volume in 1 s at week 4; these differences were no longer significantly different from week 12 onwards. TB-IRIS did not significantly impair lung function outcome.Residual pulmonary impairment is common in HIV-associated TB. In patients with low CD4 counts, neither prophylactic prednisone as used in our study nor the development of TB-IRIS significantly affected week-28 pulmonary outcome.Post-tuberculosis lung disease is common in patients with HIV-associated TB at high risk of TB-IRIS (CD4 count ≤100 cells·μL−1). Neither TB-IRIS itself, nor prednisone treatment, affected long-term pulmonary outcomes in a South African clinical setting. http://bit.ly/2RjMl9c