@article {Bouvard1900169作者= {Bouvard,克莱尔和麝猫,Nafiisha和表象,卡罗尔和骑马,巴普蒂斯特Thuillet,拉法{\ " e} l和Tu, Ly州,和罗毕拉德保罗和Campagnac Marilyne Soleti, Raffaella杜马斯De La罗克,埃里克和Delcambre市,Fr {} \ ' e d {\ ' e}里克和裙带,劳伦和Parpaite Thibaud Maurat,伊莉斯伯格,帕特里克和Savineau jean - pierre Marthan,罗杰和Guignabert,克利斯朵夫和Freund-Michel V {\ ' e} ronique吉伯特,Christelle}, title = {Connexin-43肺动脉高压是一种很有前途的目标由于hypoxaemic肺病},体积= {55}= {3},elocation-id = {1900169} = {2020}, doi = {10.1183/13993003.00169 -2019},肺动脉高压(PH)的机制是188bet官网地址复杂和多因素的，涉及不同类型的细胞，这些细胞通过缝隙连接通道相互连接。尽管连接蛋白(Cx)-43是心脏和肺中最丰富的缝隙连接蛋白，并严重控制细胞间的信号传递，但其对PH的贡献尚不清楚。本研究的重点是这样评价Cx43作为一个潜在的新的目标在Cx37 PH.Expressions Cx40和Cx43研究特发性肺动脉高血压患者肺标本(IPAH)或PH值与慢性hypoxaemic肺疾病(慢性低氧诱导肺动脉高压(CH-PH))。12周龄杂合Cx43基因敲减CD1小鼠(Cx43+/-)和野生型同窝小鼠(Cx43+/+)随机分为两组，一组室内空气饲养，另一组缺氧(10\%氧气)饲养3周。我们评估了肺血流动力学、心脏组织和肺动脉(PAs)重构过程、肺炎症和PA血管反应性。CH-PH患者PAs中Cx43水平升高，IPAH患者PAs中Cx43水平降低;然而，Cx37和Cx40水平没有差异。与Cx43+/+小鼠相比，在缺氧处理下，Cx43+/-小鼠对CH-PH具有部分保护作用，肺动脉肌肉化和炎症浸润减少。有趣的是，Cx43+/-小鼠心脏重构的适应性变化没有受到影响。 PA contraction due to endothelin-1 (ET-1) was increased in Cx43+/- mice under normoxic and hypoxic conditions.Taken together, these results indicate that targeting Cx43 may have beneficial therapeutic effects in PH without affecting compensatory cardiac hypertrophy.Connexin (Cx)-43, part of intercellular channels, is increased in patients with chronic hypoxia-induced pulmonary hypertension (CH-PH). It is crucial in lung inflammation and pulmonary artery remodelling in mice with CH-PH, suggesting Cx43 as a therapeutic option http://bit.ly/35zNkGm}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/3/1900169}, eprint = {//www.qdcxjkg.com/content/55/3/1900169.full.pdf}, journal = {European Respiratory Journal} }